DC Field | Value | Language |
---|---|---|
dc.contributor.advisor | 이현주 | - |
dc.contributor.author | Jo, Yehhyun | - |
dc.contributor.author | 조예현 | - |
dc.date.accessioned | 2024-07-26T19:31:17Z | - |
dc.date.available | 2024-07-26T19:31:17Z | - |
dc.date.issued | 2022 | - |
dc.identifier.uri | http://library.kaist.ac.kr/search/detail/view.do?bibCtrlNo=1051083&flag=dissertation | en_US |
dc.identifier.uri | http://hdl.handle.net/10203/321063 | - |
dc.description | 학위논문(석사) - 한국과학기술원 : 전기및전자공학부, 2022.2,[iii, 46 p. :] | - |
dc.description.abstract | Targeted ultrasound stimulation as a therapeutic method for investigating and treating sleep-related disorders has been hindered by the lack of robust and chronic freely moving systems in preclinical studies. Here, we propose sleep and memory modulation in freely moving mice using a microelectromechanical system (MEMS)-based ultrasound transducer and closed-loop system capable of real-time stimulation and simultaneous electrophysiological recording. By targeting the medial prefrontal cortex (mPFC) of mice, we demonstrate an increase in rapid eye movement (REM) sleep and neuroprotective effects to REM sleep deprivation (SD) in spatial working memory. The REM sleep duration remained elevated on the day after stimulation which indicates a chronic effect of ultrasound stimulation. Thus, this work demonstrates the potential of ultrasound-based acoustoceuticals as a therapeutic tool for delineating and treating sleep-related diseases. | - |
dc.language | eng | - |
dc.publisher | 한국과학기술원 | - |
dc.subject | 초음파 뇌자극▼a전두엽▼a수면▼a공간 기억력▼a자유 행동▼a쥐 | - |
dc.subject | Ultrasound stimulation▼aPrefrontal cortex▼aREM sleep▼aSpatial working memory▼aFreely moving▼aBehaving animals | - |
dc.title | Transcranial ultrasound stimulation for sleep and memory modulation in freely-moving mice | - |
dc.title.alternative | 자유행동 쥐의 수면 및 기억력 제어를 위한 초음파 전두엽 자극 시스템 개발 | - |
dc.type | Thesis(Master) | - |
dc.identifier.CNRN | 325007 | - |
dc.description.department | 한국과학기술원 :전기및전자공학부, | - |
dc.contributor.alternativeauthor | Lee, Hyunjoo Jenny | - |
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