DC Field | Value | Language |
---|---|---|
dc.contributor.advisor | 박지호 | - |
dc.contributor.author | Jang, Min-Cheol | - |
dc.contributor.author | 장민철 | - |
dc.date.accessioned | 2024-07-26T19:31:17Z | - |
dc.date.available | 2024-07-26T19:31:17Z | - |
dc.date.issued | 2022 | - |
dc.identifier.uri | http://library.kaist.ac.kr/search/detail/view.do?bibCtrlNo=1051080&flag=dissertation | en_US |
dc.identifier.uri | http://hdl.handle.net/10203/321060 | - |
dc.description | 학위논문(석사) - 한국과학기술원 : 바이오및뇌공학과, 2022.2,[iii, 21 p. :] | - |
dc.description.abstract | After the declaration of a global pandemic caused by the COVID-19, the development of therapeutic drugs using inhalation delivery of mRNA is drawing a huge attention. Currently, the most widely known mRNA carriers are ionizable lipid nanoparticles (LNPs), which compensate for the shortcomings of previously known cationic lipid particles. However, because of the structural instability coming from shearing stress of aerosolization process and the disturbance of the pulmonary surfactant layer in the human body, papers have been continuously published that LNP is not efficient in delivering mRNA into the lungs. Therefore, in this study, we develop an mRNA-liposome complex based on animal-derived pulmonary surfactant that can deliver mRNA into the lungs and overcome the disadvantages of the existing LNPs. | - |
dc.language | eng | - |
dc.publisher | 한국과학기술원 | - |
dc.subject | mRNA▼a폐 계면활성제▼a이온화성 지질 나노입자▼a리포좀▼a흡입▼a에어로졸화 | - |
dc.subject | Pulmonary surfactant▼aIonizable lipid nanoparticle▼aliposome▼ainhalation▼aaerosolization | - |
dc.subject | mRNA | - |
dc.title | Pulmonary surfactant based liposome complex for inhalation delivery of mRNA | - |
dc.title.alternative | 폐 계면활성제를 활용한 흡입 전달용 mRNA-리포좀 복합체 개발 | - |
dc.type | Thesis(Master) | - |
dc.identifier.CNRN | 325007 | - |
dc.description.department | 한국과학기술원 :바이오및뇌공학과, | - |
dc.contributor.alternativeauthor | Park, Ji-Ho | - |
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