DC Field | Value | Language |
---|---|---|
dc.contributor.advisor | 정민환 | - |
dc.contributor.author | Kim, Joowon | - |
dc.contributor.author | 김주원 | - |
dc.date.accessioned | 2024-07-26T19:30:47Z | - |
dc.date.available | 2024-07-26T19:30:47Z | - |
dc.date.issued | 2023 | - |
dc.identifier.uri | http://library.kaist.ac.kr/search/detail/view.do?bibCtrlNo=1047041&flag=dissertation | en_US |
dc.identifier.uri | http://hdl.handle.net/10203/320923 | - |
dc.description | 학위논문(박사) - 한국과학기술원 : 의과학대학원, 2023.8,[iii, 48 p. :] | - |
dc.description.abstract | Social and reward signal processing and their association are critical elements of social motivation. Despite the use of reward learning to improve the social interactions of patients with autism spectrum disorder (ASD), the underlying neural mechanisms are unknown. Here, we found different yet conjunct neuronal representations of social and reward signals in the mouse medial prefrontal cortex (mPFC). We also found that social signal processing is selectively disrupted, whereas reward signal processing is intact in the mPFC of Shank2-knockout mice, a mouse model of ASD. Furthermore, reward learning not only allows Shank2-knockout mice to associate social stimuli with reward availability, but also rescues the impaired social signal processing. These findings establish a neural basis for the therapeutic use of reward learning in ASD. | - |
dc.language | eng | - |
dc.publisher | 한국과학기술원 | - |
dc.subject | 사회 신호 처리▼a보상 학습▼a자폐증▼a내측 전전두피질▼a생체 내 칼슘 이미징 | - |
dc.subject | Social signal processing▼aReward learning▼aAutism▼aMedial prefrontal cortex▼aIn vivo calcium imaging | - |
dc.title | Improvement of social signal processing with reward learning in an autism model | - |
dc.title.alternative | 자폐 모델에서의 보상 학습을 통한 사회적 신호 처리의 개선 | - |
dc.type | Thesis(Ph.D) | - |
dc.identifier.CNRN | 325007 | - |
dc.description.department | 한국과학기술원 :의과학대학원, | - |
dc.contributor.alternativeauthor | Jung, Min Whan | - |
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