DC Field | Value | Language |
---|---|---|
dc.contributor.advisor | 고규영 | - |
dc.contributor.author | Choi, Jeongwoon | - |
dc.contributor.author | 최정운 | - |
dc.date.accessioned | 2024-07-26T19:30:47Z | - |
dc.date.available | 2024-07-26T19:30:47Z | - |
dc.date.issued | 2023 | - |
dc.identifier.uri | http://library.kaist.ac.kr/search/detail/view.do?bibCtrlNo=1047040&flag=dissertation | en_US |
dc.identifier.uri | http://hdl.handle.net/10203/320922 | - |
dc.description | 학위논문(박사) - 한국과학기술원 : 의과학대학원, 2023.8,[iii, 64 p. :] | - |
dc.description.abstract | STING, as a molecule contributing to generation of type I Interferon (IFN), has been widely researched in relation to diverse inflammatory diseases. In addition to inflammatory diseases, STING activation plays an important role in anti-tumor therapy, and much effort has been undertaken to investigate STING pathway in cancer until now. However, studies have focused on its role in immune cells primarily in the primary tumor. In this thesis, I studied the role of STING in regulation of metastasis, specifically lymph node metastasis. Using single-cell analysis and endothelial-specific STING knockout mouse, I narrowed down to the role of endothelial STING. Especially, I aimed to investigate the underlying mechanism by observing the effects of STING pathway activation in the endothelial cells constituting high endothelial venules (HEVs) and the related alterations in lymph node. | - |
dc.language | eng | - |
dc.publisher | 한국과학기술원 | - |
dc.subject | 림프절 전이▼a혈관내피세포▼a고내피세정맥▼a스팅▼a인터페론 유전자 촉진제▼a제 1형 인터페론 | - |
dc.subject | Lymph node metastasis▼aEndothelial cell▼aHigh endothelial venules▼aSTING▼aStimulator of interferon genes▼aType I Interferon | - |
dc.title | Regulation of lymph node metastasis by endothelial STING | - |
dc.title.alternative | 혈관내피세포 내 STING의 림프절 전이 조절 역할에 대한 연구 | - |
dc.type | Thesis(Ph.D) | - |
dc.identifier.CNRN | 325007 | - |
dc.description.department | 한국과학기술원 :의과학대학원, | - |
dc.contributor.alternativeauthor | Koh, Gou Young | - |
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