DC Field | Value | Language |
---|---|---|
dc.contributor.advisor | 최정균 | - |
dc.contributor.author | Kim, Jeong Yeon | - |
dc.contributor.author | 김정연 | - |
dc.date.accessioned | 2024-07-26T19:30:33Z | - |
dc.date.available | 2024-07-26T19:30:33Z | - |
dc.date.issued | 2023 | - |
dc.identifier.uri | http://library.kaist.ac.kr/search/detail/view.do?bibCtrlNo=1046629&flag=dissertation | en_US |
dc.identifier.uri | http://hdl.handle.net/10203/320857 | - |
dc.description | 학위논문(박사) - 한국과학기술원 : 바이오및뇌공학과, 2023.8,[iii, 81 p. :] | - |
dc.description.abstract | Despite advances in predicting physical peptide-major histocompatibility complex I (pMHC I) binding, it remains challenging to identify functionally immunogenic neoepitopes, especially for MHC II. By using the results of >36,000 immunogenicity assay, we developed an algorithm to identify pMHC whose structural alignment facilitates T cell reaction. The algorithm was extensively tested on collected data and our mouse experiment. Our method predicted neoepitopes for MHC I and MHC II that were responsive to checkpoint blockade when applied to >1,200 samples of various tumor types. To investigate selection by spontaneous immunity at the single epitope level, we analyzed the frequency spectrum of >25 million mutations in >9,000 treatment-naive tumors with >100 immune phenotypes. MHC II immunogenicity specifically lowered variant frequencies in tumors under high immune pressure, particularly with high TCR clonality and MHC II expression. A similar trend was shown for MHC I neoepitopes, but only in particular tissue types. In summary, we report immune selection imposed by MHC II-restricted natural or therapeutic T cell reactivity. | - |
dc.language | eng | - |
dc.publisher | 한국과학기술원 | - |
dc.subject | 신생항원▼a딥러닝▼a선택적 제거 | - |
dc.subject | Neoantigen▼aDeep-learning▼aNegative selection | - |
dc.title | Identification and systemic analyses of immunogenic neoantigens in human cancers | - |
dc.title.alternative | 면역 원성을 가지는 신생항원 예측 및 암에서의 항암반응성 시스템적인 규명 | - |
dc.type | Thesis(Ph.D) | - |
dc.identifier.CNRN | 325007 | - |
dc.description.department | 한국과학기술원 :바이오및뇌공학과, | - |
dc.contributor.alternativeauthor | Choi, Jung Kyoon | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.