DC Field | Value | Language |
---|---|---|
dc.contributor.advisor | 박지호 | - |
dc.contributor.author | Kim, Na Yeon | - |
dc.contributor.author | 김나연 | - |
dc.date.accessioned | 2024-07-25T19:30:11Z | - |
dc.date.available | 2024-07-25T19:30:11Z | - |
dc.date.issued | 2021 | - |
dc.identifier.uri | http://library.kaist.ac.kr/search/detail/view.do?bibCtrlNo=1044777&flag=dissertation | en_US |
dc.identifier.uri | http://hdl.handle.net/10203/320377 | - |
dc.description | 학위논문(석사) - 한국과학기술원 : 바이오및뇌공학과, 2021.2,[iv, 29 p. :] | - |
dc.description.abstract | Modulation of the immunosuppressive tumor microenvironment (TME) has become the key for successful cancer immunotherapy because the suppression interferes with an effective anti-tumor immunity. Among several means of TME modulation, introducing pro-inflammatory macrophages has gained attention for their role in secreting pro-inflammatory cytokines and chemokines. Despite such anti-tumoral characteristics, macrophage-mediated modulation has been challenged by the lack of trafficking ability and immunosuppressive TME that forces anti-inflammatory repolarization. This study proposes a system of monocytes loaded with pro-inflammatory drug-encapsulating particles that modulates the immunosuppressive TME into the immunostimulatory environment. This system, benefiting from both active targeting of monocytes and continuous robustness against the pro-tumoral environment by optimized particles, is expected to create the immunostimulatory environment for effective cancer immunotherapy. | - |
dc.language | eng | - |
dc.publisher | 한국과학기술원 | - |
dc.subject | 항암 면역 치료▼a종양 미세 환경▼a단핵구▼a지속 방출▼a염증성 대식세포 | - |
dc.subject | Cancer immunotherapy▼aTumor microenvironment▼aMonocyte▼aSustained release▼aPro-inflammatory macrophage | - |
dc.title | Monocytes loaded with pro-inflammatory drug-encapsulating particles for prolonged modulation of the immunosuppressive tumor microenvironment | - |
dc.title.alternative | 면역 억제적 종양 미세환경의 조절을 위한 염증성 약물 입자 탑재 단핵구 개발 | - |
dc.type | Thesis(Master) | - |
dc.identifier.CNRN | 325007 | - |
dc.description.department | 한국과학기술원 :바이오및뇌공학과, | - |
dc.contributor.alternativeauthor | Park, Ji-ho | - |
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