DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, Sang Mo | ko |
dc.contributor.author | Kim, Hyoyong | ko |
dc.contributor.author | Li, Pei | ko |
dc.contributor.author | Park, Hyun Gyu | ko |
dc.date.accessioned | 2024-06-25T12:00:10Z | - |
dc.date.available | 2024-06-25T12:00:10Z | - |
dc.date.created | 2024-06-25 | - |
dc.date.created | 2024-06-25 | - |
dc.date.issued | 2024-04 | - |
dc.identifier.citation | BIOSENSORS & BIOELECTRONICS, v.250 | - |
dc.identifier.issn | 0956-5663 | - |
dc.identifier.uri | http://hdl.handle.net/10203/320013 | - |
dc.description.abstract | We herein developed a label-free and washing-free method to detect biological thiols (biothiols) on a personal glucose meter (PGM) utilizing the intrinsic glucose oxidase (GOx)-mimicking activity of gold nanoparticles (AuNPs). By focusing on the fact that this activity could be diminished by target biothiols through their binding onto the AuNP surface, we correlated the concentration of biothiols with that of glucose readily measurable on a PGM and successfully determined cysteine (Cys), homocysteine (Hcy), and glutathione (GSH) down to 0.116, 0.059, and 0.133 mu M, respectively, with high specificity against non-target biomolecules. We further demonstrated its practical applicability by reliably detecting target biothiol in heterogeneous human serum. Due to the meritorious features of PGM such as simplicity, portability, and cost-effectiveness, we believe that this work could serve as a powerful platform for biothiol detection in point-of-care settings. | - |
dc.language | English | - |
dc.publisher | ELSEVIER ADVANCED TECHNOLOGY | - |
dc.title | A label-free and washing-free method to detect biological thiols on a personal glucose meter utilizing glucose oxidase-mimicking activity of gold nanoparticles | - |
dc.type | Article | - |
dc.identifier.wosid | 001175234800001 | - |
dc.identifier.scopusid | 2-s2.0-85183194354 | - |
dc.type.rims | ART | - |
dc.citation.volume | 250 | - |
dc.citation.publicationname | BIOSENSORS & BIOELECTRONICS | - |
dc.identifier.doi | 10.1016/j.bios.2024.116019 | - |
dc.contributor.localauthor | Park, Hyun Gyu | - |
dc.description.isOpenAccess | N | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | Biological thiol | - |
dc.subject.keywordAuthor | Personal glucose meter | - |
dc.subject.keywordAuthor | Gold nanoparticle | - |
dc.subject.keywordAuthor | Glucose oxidase-mimicking activity | - |
dc.subject.keywordPlus | CYSTEINE PROTEINASES | - |
dc.subject.keywordPlus | PLASMA | - |
dc.subject.keywordPlus | QUANTIFICATION | - |
dc.subject.keywordPlus | GLUTATHIONE | - |
dc.subject.keywordPlus | PROBES | - |
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