Hippocampal Perfusion Affects Motor and Cognitive Functions in Parkinson Disease: An Early Phase 18F-FP-CIT Positron Emission Tomography Study

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dc.contributor.authorChun, Min Youngko
dc.contributor.authorChung, Seok Jongko
dc.contributor.authorKim, Su Hongko
dc.contributor.authorPark, Chan Wookko
dc.contributor.authorJeong, Seong Hoko
dc.contributor.authorLee, Hye Sunko
dc.contributor.authorLee, Phil Hyuko
dc.contributor.authorSohn, Young H.ko
dc.contributor.authorJeong, Yongko
dc.contributor.authorKim, Yun Joongko
dc.date.accessioned2024-06-07T08:01:22Z-
dc.date.available2024-06-07T08:01:22Z-
dc.date.created2023-11-30-
dc.date.issued2024-02-
dc.identifier.citationANNALS OF NEUROLOGY, v.95, no.2, pp.388 - 399-
dc.identifier.issn0364-5134-
dc.identifier.urihttp://hdl.handle.net/10203/319672-
dc.description.abstractObjective: We investigated whether hippocampal perfusion changes are associated with cognitive decline, motor deficits, and the risk of dementia conversion in patients with Parkinson disease (PD). Methods: We recruited patients with newly diagnosed and nonmedicated PD and healthy participants who underwent dual phase 18F-N-(3-fluoropropyl)-2β-carboxymethoxy-3β-(4-iodophenyl) nortropane positron emission tomography scans. Patients were classified into 3 groups according to hippocampal perfusion measured by standard uptake value ratios (SUVRs): (1) PD hippocampal hypoperfusion group (1 standard deviation [SD] below the mean hippocampal SUVR of healthy controls; PD-hippo-hypo), (2) PD hippocampal hyperperfusion group (1 SD above the mean; PD-hippo-hyper), and (3) the remaining patients (PD-hippo-normal). We compared the baseline cognitive performance, severity of motor deficits, hippocampal volume, striatal dopamine transporter (DAT) availability, and risk of dementia conversion among the groups. Results: We included 235 patients (PD-hippo-hypo, n = 21; PD-hippo-normal, n = 157; PD-hippo-hyper, n = 57) and 48 healthy participants. Patients in the PD-hippo-hypo group were older and had smaller hippocampal volumes than those in the other PD groups. The PD-hippo-hypo group showed less severely decreased DAT availability in the putamen than the other groups despite similar severities of motor deficit. The PD-hippo-hypo group had a higher risk of dementia conversion compared to the PD-hippo-normal (hazard ratio = 2.59, p = 0.013) and PD-hippo-hyper (hazard ratio = 3.73, p = 0.006) groups, despite similar cognitive performance at initial assessment between groups. Interpretation: Hippocampal hypoperfusion may indicate a reduced capacity to cope with neurodegenerative processes in terms of the development of motor deficits and cognitive decline in patients with PD. ANN NEUROL 2024;95:388–399.-
dc.languageEnglish-
dc.publisherWILEY-
dc.titleHippocampal Perfusion Affects Motor and Cognitive Functions in Parkinson Disease: An Early Phase 18F-FP-CIT Positron Emission Tomography Study-
dc.typeArticle-
dc.identifier.wosid001114875200001-
dc.identifier.scopusid2-s2.0-85178067266-
dc.type.rimsART-
dc.citation.volume95-
dc.citation.issue2-
dc.citation.beginningpage388-
dc.citation.endingpage399-
dc.citation.publicationnameANNALS OF NEUROLOGY-
dc.identifier.doi10.1002/ana.26827-
dc.contributor.localauthorJeong, Yong-
dc.contributor.nonIdAuthorChun, Min Young-
dc.contributor.nonIdAuthorChung, Seok Jong-
dc.contributor.nonIdAuthorPark, Chan Wook-
dc.contributor.nonIdAuthorJeong, Seong Ho-
dc.contributor.nonIdAuthorLee, Hye Sun-
dc.contributor.nonIdAuthorLee, Phil Hyu-
dc.contributor.nonIdAuthorSohn, Young H.-
dc.contributor.nonIdAuthorKim, Yun Joong-
dc.description.isOpenAccessN-
dc.type.journalArticleArticle; Early Access-
dc.subject.keywordPlusCLINICAL DIAGNOSTIC-CRITERIA-
dc.subject.keywordPlusINCIDENT DEMENTIA-
dc.subject.keywordPlusIMPAIRMENT-
dc.subject.keywordPlusRESERVE-
dc.subject.keywordPlusAGE-
dc.subject.keywordPlusRECOMMENDATIONS-
dc.subject.keywordPlusAMYGDALA-
dc.subject.keywordPlusNETWORK-
dc.subject.keywordPlusATROPHY-
dc.subject.keywordPlusSYSTEM-
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