DC Field | Value | Language |
---|---|---|
dc.contributor.author | Youk, Jeonghwan | ko |
dc.contributor.author | Kwon, Hyun Woo | ko |
dc.contributor.author | Lim, Joonoh | ko |
dc.contributor.author | Kim, Eunji | ko |
dc.contributor.author | Kim, Taewoo | ko |
dc.contributor.author | Kim, Ryul | ko |
dc.contributor.author | Park, Seongyeol | ko |
dc.contributor.author | Yi, Kijong | ko |
dc.contributor.author | Nam, Chang Hyun | ko |
dc.contributor.author | Jeon, Sara | ko |
dc.contributor.author | An, Yohan | ko |
dc.contributor.author | Choi, Jinwook | ko |
dc.contributor.author | Na, Hyelin | ko |
dc.contributor.author | Lee, Eon-Seok | ko |
dc.contributor.author | Cho, Youngwon | ko |
dc.contributor.author | Min, Dong-Wook | ko |
dc.contributor.author | Kim, HyoJin | ko |
dc.contributor.author | Kang, Yeong-Rok | ko |
dc.contributor.author | Choi, Si Ho | ko |
dc.contributor.author | Bae, Min Ji | ko |
dc.contributor.author | Lee, Chang Geun | ko |
dc.contributor.author | Kim, Joon-Goon | ko |
dc.contributor.author | Kim, Young Seo | ko |
dc.contributor.author | Yu, Tosol | ko |
dc.contributor.author | Lee, Won-Chul | ko |
dc.contributor.author | Shin, Jong-Yeon | ko |
dc.contributor.author | Lee, Dong Soo | ko |
dc.contributor.author | Kim, Tae-You | ko |
dc.contributor.author | Ku, Taeyun | ko |
dc.contributor.author | Kim, Su Yeon | ko |
dc.contributor.author | Lee, Joo-Hyeon | ko |
dc.contributor.author | Koo, Bon-Kyoung | ko |
dc.contributor.author | Lee, Hyunsook | ko |
dc.contributor.author | Yi, On Vox | ko |
dc.contributor.author | Han, Eon Chul | ko |
dc.contributor.author | Chang, Ji Hyun | ko |
dc.contributor.author | Kim, Kyung Su | ko |
dc.contributor.author | Son, Tae Gen | ko |
dc.contributor.author | Ju, Youngseok | ko |
dc.date.accessioned | 2024-06-07T08:00:53Z | - |
dc.date.available | 2024-06-07T08:00:53Z | - |
dc.date.created | 2024-06-07 | - |
dc.date.created | 2024-06-07 | - |
dc.date.created | 2024-06-07 | - |
dc.date.issued | 2024-02 | - |
dc.identifier.citation | Cell Genomics, v.4, no.2 | - |
dc.identifier.issn | 2666-979X | - |
dc.identifier.uri | http://hdl.handle.net/10203/319669 | - |
dc.description.abstract | The comprehensive genomic impact of ionizing radiation (IR), a carcinogen, on healthy somatic cells remains unclear. Using large-scale whole-genome sequencing (WGS) of clones expanded from irradiated murine and human single cells, we revealed that IR induces a characteristic spectrum of short insertions or deletions (indels) and structural variations (SVs), including balanced inversions, translocations, composite SVs (deletion-insertion, deletion-inversion, and deletion-translocation composites), and complex genomic rearrangements (CGRs), including chromoplexy, chromothripsis, and SV by breakage-fusion-bridge cycles. Our findings suggest that 1 Gy IR exposure causes an average of 2.33 mutational events per Gb genome, comprising 2.15 indels, 0.17 SVs, and 0.01 CGRs, despite a high level of inter-cellular stochasticity. The mutational burden was dependent on total irradiation dose, regardless of dose rate or cell type. The findings were further validated in IR-induced secondary cancers and single cells without clonalization. Overall, our study highlights a comprehensive and clear picture of IR effects on normal mammalian genomes. | - |
dc.language | English | - |
dc.publisher | Cell Press | - |
dc.title | Quantitative and qualitative mutational impact of ionizing radiation on normal cells | - |
dc.type | Article | - |
dc.identifier.scopusid | 2-s2.0-85184798613 | - |
dc.type.rims | ART | - |
dc.citation.volume | 4 | - |
dc.citation.issue | 2 | - |
dc.citation.publicationname | Cell Genomics | - |
dc.identifier.doi | 10.1016/j.xgen.2024.100499 | - |
dc.contributor.localauthor | Ku, Taeyun | - |
dc.contributor.localauthor | Ju, Youngseok | - |
dc.contributor.nonIdAuthor | Youk, Jeonghwan | - |
dc.contributor.nonIdAuthor | Kwon, Hyun Woo | - |
dc.contributor.nonIdAuthor | Lim, Joonoh | - |
dc.contributor.nonIdAuthor | Kim, Eunji | - |
dc.contributor.nonIdAuthor | Kim, Taewoo | - |
dc.contributor.nonIdAuthor | Kim, Ryul | - |
dc.contributor.nonIdAuthor | Park, Seongyeol | - |
dc.contributor.nonIdAuthor | Yi, Kijong | - |
dc.contributor.nonIdAuthor | Nam, Chang Hyun | - |
dc.contributor.nonIdAuthor | Jeon, Sara | - |
dc.contributor.nonIdAuthor | An, Yohan | - |
dc.contributor.nonIdAuthor | Choi, Jinwook | - |
dc.contributor.nonIdAuthor | Na, Hyelin | - |
dc.contributor.nonIdAuthor | Lee, Eon-Seok | - |
dc.contributor.nonIdAuthor | Cho, Youngwon | - |
dc.contributor.nonIdAuthor | Min, Dong-Wook | - |
dc.contributor.nonIdAuthor | Kim, HyoJin | - |
dc.contributor.nonIdAuthor | Kang, Yeong-Rok | - |
dc.contributor.nonIdAuthor | Choi, Si Ho | - |
dc.contributor.nonIdAuthor | Bae, Min Ji | - |
dc.contributor.nonIdAuthor | Lee, Chang Geun | - |
dc.contributor.nonIdAuthor | Kim, Joon-Goon | - |
dc.contributor.nonIdAuthor | Kim, Young Seo | - |
dc.contributor.nonIdAuthor | Yu, Tosol | - |
dc.contributor.nonIdAuthor | Lee, Won-Chul | - |
dc.contributor.nonIdAuthor | Shin, Jong-Yeon | - |
dc.contributor.nonIdAuthor | Lee, Dong Soo | - |
dc.contributor.nonIdAuthor | Kim, Tae-You | - |
dc.contributor.nonIdAuthor | Kim, Su Yeon | - |
dc.contributor.nonIdAuthor | Lee, Joo-Hyeon | - |
dc.contributor.nonIdAuthor | Koo, Bon-Kyoung | - |
dc.contributor.nonIdAuthor | Lee, Hyunsook | - |
dc.contributor.nonIdAuthor | Yi, On Vox | - |
dc.contributor.nonIdAuthor | Han, Eon Chul | - |
dc.contributor.nonIdAuthor | Chang, Ji Hyun | - |
dc.contributor.nonIdAuthor | Kim, Kyung Su | - |
dc.contributor.nonIdAuthor | Son, Tae Gen | - |
dc.description.isOpenAccess | N | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordPlus | ADULT STEM-CELLS | - |
dc.subject.keywordPlus | SOMATIC MUTATIONS | - |
dc.subject.keywordPlus | READ ALIGNMENT | - |
dc.subject.keywordPlus | COPY NUMBER | - |
dc.subject.keywordPlus | DNA-DAMAGE | - |
dc.subject.keywordPlus | R PACKAGE | - |
dc.subject.keywordPlus | IN-VITRO | - |
dc.subject.keywordPlus | CANCER | - |
dc.subject.keywordPlus | SIGNATURES | - |
dc.subject.keywordPlus | ORGANOIDS | - |
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