Mutant microorganism producing succinic acid using substrate inhibition-relieved malate dehydrogenase and method for preparing succinic acid using the same고활성의 말산 탈수소효소가 도입된 숙신산 생성용 변이 미생물 및 이를 이용한 숙신산 제조방법

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dc.contributor.authorLee, Sang Yupko
dc.contributor.authorKim, Kyung-Jinko
dc.contributor.authorAhn, Jung Hoko
dc.contributor.authorSeo, Hogyunko
dc.contributor.authorLee, Jong Anko
dc.date.accessioned2024-05-24T03:00:34Z-
dc.date.available2024-05-24T03:00:34Z-
dc.identifier.urihttp://hdl.handle.net/10203/319484-
dc.description.abstractDisclosed are a mutant microorganism for producing succinic acid exhibiting improved activity of conversion of oxaloacetate to malate through the introduction of genes encoding a malate dehydrogenase, wherein an amino acid residue that interacts with a pyrophosphate moiety of NADH through an amide functional group of a main chain of malate dehydrogenase is glutamine (Gln), and a method of producing succinic acid using the same. The mutant microorganism producing succinic acid according to the present invention is capable of producing a high concentration of succinic acid at the highest productivity compared to other mutant microorganisms reported to date when the microorganism is cultured in a limited medium. In addition, the mutant microorganism is capable of producing succinic acid at higher productivity and product concentration through further advanced fermentation technology.-
dc.titleMutant microorganism producing succinic acid using substrate inhibition-relieved malate dehydrogenase and method for preparing succinic acid using the same-
dc.title.alternative고활성의 말산 탈수소효소가 도입된 숙신산 생성용 변이 미생물 및 이를 이용한 숙신산 제조방법-
dc.typePatent-
dc.type.rimsPAT-
dc.contributor.localauthorLee, Sang Yup-
dc.contributor.nonIdAuthorKim, Kyung-Jin-
dc.contributor.nonIdAuthorSeo, Hogyun-
dc.contributor.assigneeKAIST-
dc.identifier.iprsType특허-
dc.identifier.patentApplicationNumber16490515-
dc.identifier.patentRegistrationNumber11655462-
dc.date.application2019-05-02-
dc.date.registration2023-05-23-
dc.publisher.countryUS-
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CBE-Patent(특허)
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