DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kakizaki, Miyo | ko |
dc.contributor.author | Tsuneoka, Yousuke | ko |
dc.contributor.author | Takase, Kenkichi | ko |
dc.contributor.author | Kim, Staci Jakyong | ko |
dc.contributor.author | Choi, Jinhwan | ko |
dc.contributor.author | Ikkyu, Aya | ko |
dc.contributor.author | Abe, Manabu | ko |
dc.contributor.author | Sakimura, Kenji | ko |
dc.contributor.author | Yanagisawa, Masashi | ko |
dc.contributor.author | Funato, Hiromasa | ko |
dc.date.accessioned | 2024-04-24T03:00:15Z | - |
dc.date.available | 2024-04-24T03:00:15Z | - |
dc.date.created | 2024-04-24 | - |
dc.date.created | 2024-04-24 | - |
dc.date.created | 2024-04-24 | - |
dc.date.created | 2024-04-24 | - |
dc.date.issued | 2019-10 | - |
dc.identifier.citation | ISCIENCE, v.20, pp.1 - 13 | - |
dc.identifier.issn | 2589-0042 | - |
dc.identifier.uri | http://hdl.handle.net/10203/319221 | - |
dc.description.abstract | Orexins are hypothalamic neuropeptides that regulate feeding, energy expenditure, and sleep. Although orexin-deficient mice are susceptible to obesity, little is known about the roles of the orexin receptors in long-term energy metabolism. Here, we performed the metabolic characterization of orexin receptor-deficient mice. Ox1r-deficient mice were resistant to diet-induced obesity, and their food intake was similar between chow and high-fat food. Ox2r-deficient mice exhibited less energy expenditure than wild-type mice when fed a high-fat diet. Neither Ox1r-deficient nor Ox2r-deficient mice showed body weight gain similar to orexin-deficient mice. Although the presence of a running wheel suppressed diet-induced obesity in wild-type mice, the effect was weaker in orexin neuron-ablated mice. Finally, we did not detect abnormalities in brown adipose tissues of orexin-deficient mice. Thus, each orexin receptor signaling has a unique role in energy metabolism, and orexin neurons are involved in the interactive effect of diet and exercise on body weight gain. | - |
dc.language | English | - |
dc.publisher | CELL PRESS | - |
dc.title | Differential Roles of Each Orexin Receptor Signaling in Obesity | - |
dc.type | Article | - |
dc.identifier.wosid | 000493388000001 | - |
dc.identifier.scopusid | 2-s2.0-85072344335 | - |
dc.type.rims | ART | - |
dc.citation.volume | 20 | - |
dc.citation.beginningpage | 1 | - |
dc.citation.endingpage | 13 | - |
dc.citation.publicationname | ISCIENCE | - |
dc.identifier.doi | 10.1016/j.isci.2019.09.003 | - |
dc.contributor.localauthor | Kim, Staci Jakyong | - |
dc.contributor.nonIdAuthor | Kakizaki, Miyo | - |
dc.contributor.nonIdAuthor | Tsuneoka, Yousuke | - |
dc.contributor.nonIdAuthor | Takase, Kenkichi | - |
dc.contributor.nonIdAuthor | Choi, Jinhwan | - |
dc.contributor.nonIdAuthor | Ikkyu, Aya | - |
dc.contributor.nonIdAuthor | Abe, Manabu | - |
dc.contributor.nonIdAuthor | Sakimura, Kenji | - |
dc.contributor.nonIdAuthor | Yanagisawa, Masashi | - |
dc.contributor.nonIdAuthor | Funato, Hiromasa | - |
dc.description.isOpenAccess | N | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordPlus | DIET-INDUCED OBESITY | - |
dc.subject.keywordPlus | FOOD-CONSUMPTION | - |
dc.subject.keywordPlus | KNOCKOUT MICE | - |
dc.subject.keywordPlus | NARCOLEPSY | - |
dc.subject.keywordPlus | NEURONS | - |
dc.subject.keywordPlus | ANTAGONIST | - |
dc.subject.keywordPlus | SLEEP | - |
dc.subject.keywordPlus | DYSFUNCTION | - |
dc.subject.keywordPlus | HYPOCRETIN | - |
dc.subject.keywordPlus | ADDICTION | - |
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