DC Field | Value | Language |
---|---|---|
dc.contributor.author | Asano, Fuyuki | ko |
dc.contributor.author | Kim, Staci Jakyong | ko |
dc.contributor.author | Fujiyama, Tomoyuki | ko |
dc.contributor.author | Miyoshi, Chika | ko |
dc.contributor.author | Hotta-Hirashima, Noriko | ko |
dc.contributor.author | Asama, Nodoka | ko |
dc.contributor.author | Iwasaki, Kanako | ko |
dc.contributor.author | Kakizaki, Miyo | ko |
dc.contributor.author | Mizuno, Seiya | ko |
dc.contributor.author | Mieda, Michihiro | ko |
dc.contributor.author | Sugiyama, Fumihiro | ko |
dc.contributor.author | Takahashi, Satoru | ko |
dc.contributor.author | Shi, Shoi | ko |
dc.contributor.author | Hirano, Arisa | ko |
dc.contributor.author | Funato, Hiromasa | ko |
dc.contributor.author | Yanagisawa, Masashi | ko |
dc.date.accessioned | 2024-04-24T02:00:13Z | - |
dc.date.available | 2024-04-24T02:00:13Z | - |
dc.date.created | 2024-04-24 | - |
dc.date.created | 2024-04-24 | - |
dc.date.created | 2024-04-24 | - |
dc.date.issued | 2023-03 | - |
dc.identifier.citation | PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, v.120, no.11 | - |
dc.identifier.issn | 0027-8424 | - |
dc.identifier.uri | http://hdl.handle.net/10203/319217 | - |
dc.description.abstract | Mammals exhibit circadian cycles of sleep and wakefulness under the control of the suprachiasmatic nucleus (SCN), such as the strong arousal phase-locked to the beginning of the dark phase in laboratory mice. Here, we demonstrate that salt -induc-ible kinase 3 (SIK3) deficiency in gamma-aminobutyric acid (GABA)-ergic neurons or neuromedin S (NMS)-producing neurons delayed the arousal peak phase and lengthened the behavioral circadian cycle under both 12-h light:12-h dark condition (LD) and constant dark condition (DD) without changing daily sleep amounts. In contrast, the induction of a gain-of-function mutant allele of Sik3 in GABAergic neurons exhibited advanced activity onset and a shorter circadian period. Loss of SIK3 in arginine vasopressin (AVP)-producing neurons lengthened the circadian cycle, but the arousal peak phase was similar to that in control mice. Heterozygous deficiency of histone deacetylase (HDAC) 4, a SIK3 substrate, shortened the circa-dian cycle, whereas mice with HDAC4 S245A, which is resistant to phosphorylation by SIK3, delayed the arousal peak phase. Phase-delayed core clock gene expressions were detected in the liver of mice lacking SIK3 in GABAergic neurons. These results suggest that the SIK3-HDAC4 pathway regulates the circadian period length and the timing of arousal through NMS-positive neurons in the SCN. | - |
dc.language | English | - |
dc.publisher | NATL ACAD SCIENCES | - |
dc.title | SIK3–HDAC4 in the suprachiasmatic nucleus regulates the timing of arousal at the dark onset and circadian period in mice | - |
dc.type | Article | - |
dc.identifier.wosid | 001036990500001 | - |
dc.identifier.scopusid | 2-s2.0-85150000635 | - |
dc.type.rims | ART | - |
dc.citation.volume | 120 | - |
dc.citation.issue | 11 | - |
dc.citation.publicationname | PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | - |
dc.identifier.doi | 10.1073/pnas.2218209120 | - |
dc.contributor.localauthor | Kim, Staci Jakyong | - |
dc.contributor.nonIdAuthor | Asano, Fuyuki | - |
dc.contributor.nonIdAuthor | Fujiyama, Tomoyuki | - |
dc.contributor.nonIdAuthor | Miyoshi, Chika | - |
dc.contributor.nonIdAuthor | Hotta-Hirashima, Noriko | - |
dc.contributor.nonIdAuthor | Asama, Nodoka | - |
dc.contributor.nonIdAuthor | Iwasaki, Kanako | - |
dc.contributor.nonIdAuthor | Kakizaki, Miyo | - |
dc.contributor.nonIdAuthor | Mizuno, Seiya | - |
dc.contributor.nonIdAuthor | Mieda, Michihiro | - |
dc.contributor.nonIdAuthor | Sugiyama, Fumihiro | - |
dc.contributor.nonIdAuthor | Takahashi, Satoru | - |
dc.contributor.nonIdAuthor | Shi, Shoi | - |
dc.contributor.nonIdAuthor | Hirano, Arisa | - |
dc.contributor.nonIdAuthor | Funato, Hiromasa | - |
dc.contributor.nonIdAuthor | Yanagisawa, Masashi | - |
dc.description.isOpenAccess | N | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | SIK3 | - |
dc.subject.keywordAuthor | HDAC4 | - |
dc.subject.keywordAuthor | circadian rhythms | - |
dc.subject.keywordAuthor | circadian period | - |
dc.subject.keywordAuthor | arousal timing | - |
dc.subject.keywordPlus | CHONDROCYTE HYPERTROPHY | - |
dc.subject.keywordPlus | SLEEP-WAKE | - |
dc.subject.keywordPlus | NEURONS | - |
dc.subject.keywordPlus | DEFICIENT | - |
dc.subject.keywordPlus | RHYTHMS | - |
dc.subject.keywordPlus | PATHWAY | - |
dc.subject.keywordPlus | CLOCKS | - |
dc.subject.keywordPlus | NPAS4 | - |
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