DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Eun-Kyung | ko |
dc.contributor.author | Kwon, Kang-Beom | ko |
dc.contributor.author | Han, Mi-Jeong | ko |
dc.contributor.author | Song, Mi-Young | ko |
dc.contributor.author | Lee, Ji-Hyun | ko |
dc.contributor.author | Lv, Na | ko |
dc.contributor.author | Ka, Sun-O | ko |
dc.contributor.author | Yeom, Seung-Ryong | ko |
dc.contributor.author | Kwon, Young-Dal | ko |
dc.contributor.author | Ryu, Do-Gon | ko |
dc.contributor.author | Kim, Kang-San | ko |
dc.contributor.author | Park, Jin-Woo | ko |
dc.contributor.author | Park, Raekil | ko |
dc.contributor.author | Park, Byung-Hyun | ko |
dc.date.accessioned | 2024-03-26T07:00:20Z | - |
dc.date.available | 2024-03-26T07:00:20Z | - |
dc.date.created | 2024-03-26 | - |
dc.date.created | 2024-03-26 | - |
dc.date.created | 2024-03-26 | - |
dc.date.issued | 2007-04 | - |
dc.identifier.citation | Experimental and Molecular Medicine, v.39, no.2, pp.149 - 159 | - |
dc.identifier.issn | 1226-3613 | - |
dc.identifier.uri | http://hdl.handle.net/10203/318871 | - |
dc.description.abstract | We demonstrated previously that Coptidis rhizoma extract (CRE) prevented S-nitroso-N-acetylpeni-cillamine-induced apoptotic cell death via the in-hibition of mitochondrial membrane potential dis-ruption and cytochrome c re lease in RINm5F (RIN) rat insulinoma cells. In this study, the preventive effects of CRE against cytokine-induced β-cell death was assessed. Cytokines generated by immune cells infiltrating pancreatic islets are crucial mediators of β-cell destruction in insulin-dependent diabetes mellitus. The treatment of RIN cells with IL-1β and IFN-γ resulted in a reduction of cell viability. CRE completely protected IL-1β and IFN-γ-mediated cell death in a concentration-dependent manner. Incu-bation with CRE induced a significant suppression of IL-1β and IFN-γ-induced nitric oxide (NO) production, a finding which correlated well with reduced levels of the iNOS mRNA and protein. The molecular mecha-nism by which CRE inhibited iNOS gene expression appeared to involve the inhibition of NF-κB activa-tion. The IL-1β and IFN-γ-stimulated RIN cells showed increases in NF-κB binding activity and p65 subunit levels in nucleus, and I κBα degradation in cytosol compared to unstimulated cells. Furthermore, the protective effects of CRE were verified via the observation of reduced NO generation and iNOS expression, and normal insulin-secretion res-ponses to glucose in IL-1 β and IFN-γ-treated islets. | - |
dc.language | English | - |
dc.publisher | SPRINGERNATURE | - |
dc.title | Coptidis rhizoma extract protects against cytokine-induceddeath of pancreatic β-cells through suppression of NF-κBactivation | - |
dc.type | Article | - |
dc.identifier.wosid | 000246217600003 | - |
dc.identifier.scopusid | 2-s2.0-34247594974 | - |
dc.type.rims | ART | - |
dc.citation.volume | 39 | - |
dc.citation.issue | 2 | - |
dc.citation.beginningpage | 149 | - |
dc.citation.endingpage | 159 | - |
dc.citation.publicationname | Experimental and Molecular Medicine | - |
dc.identifier.doi | 10.1038/emm.2007.17 | - |
dc.identifier.kciid | ART001051169 | - |
dc.contributor.localauthor | Park, Byung-Hyun | - |
dc.contributor.nonIdAuthor | Kim, Eun-Kyung | - |
dc.contributor.nonIdAuthor | Kwon, Kang-Beom | - |
dc.contributor.nonIdAuthor | Han, Mi-Jeong | - |
dc.contributor.nonIdAuthor | Song, Mi-Young | - |
dc.contributor.nonIdAuthor | Lee, Ji-Hyun | - |
dc.contributor.nonIdAuthor | Lv, Na | - |
dc.contributor.nonIdAuthor | Ka, Sun-O | - |
dc.contributor.nonIdAuthor | Yeom, Seung-Ryong | - |
dc.contributor.nonIdAuthor | Kwon, Young-Dal | - |
dc.contributor.nonIdAuthor | Ryu, Do-Gon | - |
dc.contributor.nonIdAuthor | Kim, Kang-San | - |
dc.contributor.nonIdAuthor | Park, Jin-Woo | - |
dc.contributor.nonIdAuthor | Park, Raekil | - |
dc.description.isOpenAccess | N | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | cell death | - |
dc.subject.keywordAuthor | Coptidis rhizoma extract | - |
dc.subject.keywordAuthor | cytokines | - |
dc.subject.keywordAuthor | drugs, Chinese herbal | - |
dc.subject.keywordAuthor | insulin secreting cells | - |
dc.subject.keywordAuthor | NF-kappa B | - |
dc.subject.keywordAuthor | nitric oxide | - |
dc.subject.keywordPlus | NITRIC-OXIDE SYNTHASE | - |
dc.subject.keywordPlus | DEPENDENT DIABETES-MELLITUS | - |
dc.subject.keywordPlus | AMOMUM-XANTHOIDES EXTRACT | - |
dc.subject.keywordPlus | INSULIN-PRODUCING CELLS | - |
dc.subject.keywordPlus | NECROSIS-FACTOR-ALPHA | - |
dc.subject.keywordPlus | RINM5F CELLS | - |
dc.subject.keywordPlus | OXIDATIVE STRESS | - |
dc.subject.keywordPlus | GENE-TRANSFER | - |
dc.subject.keywordPlus | HUMAN ISLETSE | - |
dc.subject.keywordPlus | XPRESSION | - |
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