DC Field | Value | Language |
---|---|---|
dc.contributor.author | 송제호 | ko |
dc.contributor.author | 박병현 | ko |
dc.contributor.author | 류도곤 | ko |
dc.contributor.author | 권강범 | ko |
dc.date.accessioned | 2024-03-26T06:00:09Z | - |
dc.date.available | 2024-03-26T06:00:09Z | - |
dc.date.created | 2024-03-26 | - |
dc.date.issued | 2008-08 | - |
dc.identifier.citation | 동의생리병리학회지, v.22, no.4, pp.791 - 795 | - |
dc.identifier.uri | http://hdl.handle.net/10203/318866 | - |
dc.description.abstract | In the present study, Cordyceps sinensis extract (CSE) was evaluated to determine if it could protect pancreatic β cells against cytokine-induced cytotoxicity of RINm5F cells. Treatment of cells with cytokines resulted in a decrease of viability, which was caused by increase of nitric oxide (NO) production. CSE protected cytokine-mediated viability reduction in a concentration-dependent manner. Incubation with CSE also induced a significant suppression of cytokine-induced inducible nitric oxide synthase (iNOS) protein and NO production. The molecular mechanism by which CSE inhibited iNOS protein expression appeared to involve the inhibition of NF-κB activation. The cytokine-stimulated RIN cells showed increases in NF-κB binding activity compared to unstimulated cells. However, pretreatment with CSE inhibited cytokines-induced NF-κB activation in RINm5F cells. | - |
dc.language | Korean | - |
dc.publisher | 한의병리학회 | - |
dc.title | 싸이토카인에 의한 췌장 β세포 독성에 대한 동충하초 추출물의 보호 효과 | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.citation.volume | 22 | - |
dc.citation.issue | 4 | - |
dc.citation.beginningpage | 791 | - |
dc.citation.endingpage | 795 | - |
dc.citation.publicationname | 동의생리병리학회지 | - |
dc.identifier.kciid | ART001270526 | - |
dc.contributor.localauthor | 박병현 | - |
dc.contributor.nonIdAuthor | 송제호 | - |
dc.contributor.nonIdAuthor | 류도곤 | - |
dc.contributor.nonIdAuthor | 권강범 | - |
dc.description.isOpenAccess | N | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordPlus | cordyceps sinensis | - |
dc.subject.keywordPlus | diabetes | - |
dc.subject.keywordPlus | cytokine | - |
dc.subject.keywordPlus | nitric oxide | - |
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