DC Field | Value | Language |
---|---|---|
dc.contributor.author | Song, Mi-Young | ko |
dc.contributor.author | Kim, Eun-Kyung | ko |
dc.contributor.author | Moon, Woo-Sung | ko |
dc.contributor.author | Park, Jin-Woo | ko |
dc.contributor.author | Kim, Hyung-Jin | ko |
dc.contributor.author | So, Hong-Seob | ko |
dc.contributor.author | Park, Raekil | ko |
dc.contributor.author | Kwon, Kang-Beom | ko |
dc.contributor.author | Park, Byung-Hyun | ko |
dc.date.accessioned | 2024-03-25T01:02:11Z | - |
dc.date.available | 2024-03-25T01:02:11Z | - |
dc.date.created | 2024-03-21 | - |
dc.date.issued | 2009-02 | - |
dc.identifier.citation | TOXICOLOGY AND APPLIED PHARMACOLOGY, v.235, no.1, pp.57 - 67 | - |
dc.identifier.issn | 0041-008X | - |
dc.identifier.uri | http://hdl.handle.net/10203/318848 | - |
dc.description.abstract | Sulforaphane (SFN) is an indirect antioxidant that protects animal tissues from chemical or biological insults by stimulating the expression of several NF-E2-related factor-2 (Nrf2)-regulated phase 2 enzymes. Treatment of RINm5F insulinoma cells with SFN increases Nrf2 nuclear translocation and expression of phase 2 enzymes. In this study, we investigated whether the activation of Nrf2 by SFN treatment or ectopic overexpression of Nrf2 inhibited cytokine-induced beta-cell damage. Treatment of RIN cells with IL-1 beta and IFN-gamma induced beta 3-cell damage through a NF-kappa B-dependent signaling pathway. Activation of Nrf2 by treatment with SFN and induction of Nrf2 overexpression by transfection with Nrf2 prevented cytokine toxicity. The mechanism by which Nrf2 activation inhibited NF-kappa B-dependent cell death signals appeared to involve the reduction of oxidative stress, as demonstrated by the inhibition of cytokine-induced H2O2 production. The protective effect of SFN was further demonstrated by the restoration of normal insulin secreting responses to glucose in cytokine-treated rat pancreatic islets. Furthermore, pretreatment with SFN blocked the development of type 1 diabetes in streptozotocin-treated mice. (C) 2008 Elsevier Inc. All rights reserved. | - |
dc.language | English | - |
dc.publisher | ACADEMIC PRESS INC ELSEVIER SCIENCE | - |
dc.title | Sulforaphane protects against cytokine- and streptozotocin-induced β-cell damage by suppressing the NF-κB pathway | - |
dc.type | Article | - |
dc.identifier.wosid | 000263541600008 | - |
dc.identifier.scopusid | 2-s2.0-59149098593 | - |
dc.type.rims | ART | - |
dc.citation.volume | 235 | - |
dc.citation.issue | 1 | - |
dc.citation.beginningpage | 57 | - |
dc.citation.endingpage | 67 | - |
dc.citation.publicationname | TOXICOLOGY AND APPLIED PHARMACOLOGY | - |
dc.identifier.doi | 10.1016/j.taap.2008.11.007 | - |
dc.contributor.localauthor | Park, Byung-Hyun | - |
dc.contributor.nonIdAuthor | Song, Mi-Young | - |
dc.contributor.nonIdAuthor | Kim, Eun-Kyung | - |
dc.contributor.nonIdAuthor | Moon, Woo-Sung | - |
dc.contributor.nonIdAuthor | Park, Jin-Woo | - |
dc.contributor.nonIdAuthor | Kim, Hyung-Jin | - |
dc.contributor.nonIdAuthor | So, Hong-Seob | - |
dc.contributor.nonIdAuthor | Park, Raekil | - |
dc.contributor.nonIdAuthor | Kwon, Kang-Beom | - |
dc.description.isOpenAccess | N | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | Nrf2 | - |
dc.subject.keywordAuthor | Sulforaphane | - |
dc.subject.keywordAuthor | NF-kappa B | - |
dc.subject.keywordAuthor | beta cells | - |
dc.subject.keywordAuthor | Cytokine | - |
dc.subject.keywordPlus | PIGMENT EPITHELIAL-CELLS | - |
dc.subject.keywordPlus | HEME OXYGENASE-1 | - |
dc.subject.keywordPlus | PANCREATIC-ISLETS | - |
dc.subject.keywordPlus | OXIDATIVE STRESS | - |
dc.subject.keywordPlus | GENE-EXPRESSION | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | DESTRUCTION | - |
dc.subject.keywordPlus | INDUCTION | - |
dc.subject.keywordPlus | APOPTOSIS | - |
dc.subject.keywordPlus | TOXICITY | - |
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