DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, Hwa-Suk | ko |
dc.contributor.author | Ka, Sun-O | ko |
dc.contributor.author | Lee, Sang-Myeong | ko |
dc.contributor.author | Lee, Sang-Il | ko |
dc.contributor.author | Park, Jin-Woo | ko |
dc.contributor.author | Park, Byung-Hyun | ko |
dc.date.accessioned | 2024-03-25T01:00:49Z | - |
dc.date.available | 2024-03-25T01:00:49Z | - |
dc.date.created | 2024-03-21 | - |
dc.date.created | 2024-03-21 | - |
dc.date.issued | 2013-07 | - |
dc.identifier.citation | ARTHRITIS AND RHEUMATISM, v.65, no.7, pp.1776 - 1785 | - |
dc.identifier.issn | 0004-3591 | - |
dc.identifier.uri | http://hdl.handle.net/10203/318830 | - |
dc.description.abstract | ObjectiveSirtuin 6 (SIRT-6) is an NAD(+)-dependent deacetylase and mono-ADP-ribosyltransferase. It is known to interfere with the NF-B signaling pathway and thereby has an antiinflammatory function. Due to the central role of NF-B in rheumatoid arthritis (RA) development, we undertook this study to test our hypothesis that SIRT-6 could have antiarthritic effects. MethodsAn adenovirus containing SIRT-6 complementary DNA (Ad-SIRT6) was used to deliver SIRT-6 to human RA fibroblast-like synoviocytes in vitro as well as to mice with collagen-induced arthritis (CIA) in vivo via bilateral intraarticular injections into the ankle joints. ResultsIn vitro experiments demonstrated that SIRT-6 overexpression suppressed NF-B target gene expression induced by tumor necrosis factor . SIRT-6 overexpression inhibited osteoclast differentiation induced by macrophage colony-stimulating factor and RANKL in bone marrow-derived macrophages. Mice with CIA had an increased incidence of disease and developed arthritis in the hind paws. In contrast, mice injected with Ad-SIRT6 showed attenuated severity of arthritis based on clinical scores, hind paw thickness, and radiographic and pathologic findings. Moreover, the injection of Ad-SIRT6 down-regulated local and systemic levels of proinflammatory cytokines. After induction of CIA, mice injected with Ad-SIRT6 showed significantly decreased arthritis severity, from the onset of clinical signs to the end of the study. ConclusionThese results suggest that blocking the NF-B pathway by SIRT-6 in rheumatoid joints reduces both the inflammatory response and tissue destruction. Therefore, the development of an immunoregulatory strategy based on SIRT-6 may have therapeutic potential for the treatment of RA. | - |
dc.language | English | - |
dc.publisher | WILEY | - |
dc.title | Overexpression of Sirtuin 6 Suppresses Inflammatory Responses and Bone Destruction in Mice With Collagen-Induced Arthritis | - |
dc.type | Article | - |
dc.identifier.wosid | 000322155000013 | - |
dc.identifier.scopusid | 2-s2.0-84879858356 | - |
dc.type.rims | ART | - |
dc.citation.volume | 65 | - |
dc.citation.issue | 7 | - |
dc.citation.beginningpage | 1776 | - |
dc.citation.endingpage | 1785 | - |
dc.citation.publicationname | ARTHRITIS AND RHEUMATISM | - |
dc.identifier.doi | 10.1002/art.37963 | - |
dc.contributor.localauthor | Park, Byung-Hyun | - |
dc.contributor.nonIdAuthor | Lee, Hwa-Suk | - |
dc.contributor.nonIdAuthor | Ka, Sun-O | - |
dc.contributor.nonIdAuthor | Lee, Sang-Myeong | - |
dc.contributor.nonIdAuthor | Lee, Sang-Il | - |
dc.contributor.nonIdAuthor | Park, Jin-Woo | - |
dc.description.isOpenAccess | N | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordPlus | FIBROBLAST-LIKE SYNOVIOCYTES | - |
dc.subject.keywordPlus | DEPENDENT GENE-EXPRESSION | - |
dc.subject.keywordPlus | RHEUMATOID-ARTHRITIS | - |
dc.subject.keywordPlus | LIFE-SPAN | - |
dc.subject.keywordPlus | SACCHAROMYCES-CEREVISIAE | - |
dc.subject.keywordPlus | CALORIE RESTRICTION | - |
dc.subject.keywordPlus | DEACETYLATION | - |
dc.subject.keywordPlus | CLASSIFICATION | - |
dc.subject.keywordPlus | PATHOGENESIS | - |
dc.subject.keywordPlus | INHIBITION | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.