DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, Young-Rae | ko |
dc.contributor.author | Noh, Eun-Mi | ko |
dc.contributor.author | Oh, Hyun Ju | ko |
dc.contributor.author | Hur, Hyun | ko |
dc.contributor.author | Kim, Jeong-Mi | ko |
dc.contributor.author | Han, Ji-Hey | ko |
dc.contributor.author | Hwang, Jin-Ki | ko |
dc.contributor.author | Park, Byung-Hyun | ko |
dc.contributor.author | Park, Jin-Woo | ko |
dc.contributor.author | Youn, Hyun Jo | ko |
dc.contributor.author | Jung, Sung Hoo | ko |
dc.contributor.author | Kim, Byeong-Soo | ko |
dc.contributor.author | Jung, Ji-Youn | ko |
dc.contributor.author | Lee, Sung-Ho | ko |
dc.contributor.author | Park, Chang-Sik | ko |
dc.contributor.author | Kim, Jong-Suk | ko |
dc.date.accessioned | 2024-03-22T07:03:37Z | - |
dc.date.available | 2024-03-22T07:03:37Z | - |
dc.date.created | 2024-03-21 | - |
dc.date.issued | 2011-02 | - |
dc.identifier.citation | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, v.405, no.4, pp.552 - 557 | - |
dc.identifier.issn | 0006-291X | - |
dc.identifier.uri | http://hdl.handle.net/10203/318814 | - |
dc.description.abstract | Dihydroavenanthramide D (DHAvD) is a synthetic analog to naturally occurring avenanthramide, which is the active component of oat. Previous study demonstrates that DHAvD strongly inhibits activation of nuclear factor-kappa B (NF-kappa B), which is a major component in cancer cell invasion. The present study investigated whether DHAvD can modulate MMP-9 expression and cell invasion in MCF-7 human breast cancer cells. MMP-9 expression and cell invasion in response to 12-O-tetradecanoylphorbol-13-acetate (TPA) was increased, whereas these inductions were muted by DHAvD. DHAvD also suppressed activation of mitogen-activated protein kinase (MAPK), and MAPK-mediated nuclear factor-kappa B (NF-kappa B) and activator protein-1 (AP-1) activations in TPA-treated MCF-7 cells. The results indicate that DHAvD-mediated inhibition of TPA-induced MMP-9 expression and cell invasion involves the suppression of the MAPK/NF-kappa B and MAPK/AP-1 pathways in MCF-7 cells. DHAvD may have potential value in breast cancer metastasis. (C) 2011 Elsevier Inc. All rights reserved. | - |
dc.language | English | - |
dc.publisher | ACADEMIC PRESS INC ELSEVIER SCIENCE | - |
dc.title | Dihydroavenanthramide D inhibits human breast cancer cell invasion through suppression of MMP-9 expression | - |
dc.type | Article | - |
dc.identifier.wosid | 000288149500006 | - |
dc.identifier.scopusid | 2-s2.0-79951957724 | - |
dc.type.rims | ART | - |
dc.citation.volume | 405 | - |
dc.citation.issue | 4 | - |
dc.citation.beginningpage | 552 | - |
dc.citation.endingpage | 557 | - |
dc.citation.publicationname | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | - |
dc.identifier.doi | 10.1016/j.bbrc.2011.01.065 | - |
dc.contributor.localauthor | Park, Byung-Hyun | - |
dc.contributor.nonIdAuthor | Lee, Young-Rae | - |
dc.contributor.nonIdAuthor | Noh, Eun-Mi | - |
dc.contributor.nonIdAuthor | Oh, Hyun Ju | - |
dc.contributor.nonIdAuthor | Hur, Hyun | - |
dc.contributor.nonIdAuthor | Kim, Jeong-Mi | - |
dc.contributor.nonIdAuthor | Han, Ji-Hey | - |
dc.contributor.nonIdAuthor | Hwang, Jin-Ki | - |
dc.contributor.nonIdAuthor | Park, Jin-Woo | - |
dc.contributor.nonIdAuthor | Youn, Hyun Jo | - |
dc.contributor.nonIdAuthor | Jung, Sung Hoo | - |
dc.contributor.nonIdAuthor | Kim, Byeong-Soo | - |
dc.contributor.nonIdAuthor | Jung, Ji-Youn | - |
dc.contributor.nonIdAuthor | Lee, Sung-Ho | - |
dc.contributor.nonIdAuthor | Park, Chang-Sik | - |
dc.contributor.nonIdAuthor | Kim, Jong-Suk | - |
dc.description.isOpenAccess | N | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | DHAvD | - |
dc.subject.keywordAuthor | MMP-9 | - |
dc.subject.keywordAuthor | NF-kappa B | - |
dc.subject.keywordAuthor | AP-1 | - |
dc.subject.keywordAuthor | Metastasis | - |
dc.subject.keywordAuthor | Invasion | - |
dc.subject.keywordAuthor | MCF-7 | - |
dc.subject.keywordPlus | NF-KAPPA-B | - |
dc.subject.keywordPlus | ACTIVATED PROTEIN-KINASE | - |
dc.subject.keywordPlus | MAPK SIGNALING PATHWAYS | - |
dc.subject.keywordPlus | MATRIX METALLOPROTEINASES | - |
dc.subject.keywordPlus | MATRIX-METALLOPROTEINASE-9 EXPRESSION | - |
dc.subject.keywordPlus | TUMOR INVASION | - |
dc.subject.keywordPlus | AVENANTHRAMIDES | - |
dc.subject.keywordPlus | POLYPHENOLS | - |
dc.subject.keywordPlus | METASTASIS | - |
dc.subject.keywordPlus | SECRETION | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.