DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Soo Mi | ko |
dc.contributor.author | Ye, Shuai | ko |
dc.contributor.author | Rah, So-Young | ko |
dc.contributor.author | Park, Byung Hyun | ko |
dc.contributor.author | Wang, Hongen | ko |
dc.contributor.author | Kim, Jung-Ryul | ko |
dc.contributor.author | Kim, Seung Ho | ko |
dc.contributor.author | Jang, Kyu Yun | ko |
dc.contributor.author | Lee, Kwang-Bok | ko |
dc.date.accessioned | 2024-03-22T07:00:23Z | - |
dc.date.available | 2024-03-22T07:00:23Z | - |
dc.date.created | 2024-03-21 | - |
dc.date.issued | 2016-05 | - |
dc.identifier.citation | SCIENTIFIC REPORTS, v.6 | - |
dc.identifier.issn | 2045-2322 | - |
dc.identifier.uri | http://hdl.handle.net/10203/318773 | - |
dc.description.abstract | Despite that recombinant human bone morphogenetic protein-2 (rhBMP-2) has been reported as a stimulatory effecter of cancer cell growth because of its characteristic like morphogen, the biological functions of rhBMP-2 in human esophageal cancer cells are unknown. The purpose of this study was to investigate whether rhBMP-2 has an inhibitory effect on the growth of human esophageal squamous carcinoma cells (ESCC). RhBMP-2 significantly inhibited proliferation of ESCC cells in a dose-dependent manner in the MTT assay. Cell cycle arrest at the G1 phase was induced 24 h after rhBMP2 treatment. RhBMP-2 also reduced cyclin D1, cyclin-dependent kinase (CDK) 4 and CDK 6 activities, and stimulated p-Smad1/5/8, p53, and p21 levels at 12 h. In contrast, rhBMP-2 diminished poly (ADP-ribose) polymerase (PARP) protein expression levels and activated cleaved PARP, cleaved caspase-7, and cleaved-caspase 9 levels in ESCC cells. In addition, rhBMP-2 increased MST1, MOB1, and p-YAP protein levels and the RASSF1 binds Mst1 more upon treatment with rhBMP2. The induced p-YAP expression in TE-8 and TE-12 cells by rhBMP-2 was reversed by the RASSF1 knockdown. In vivo study, rhBMP-2 decreased tumor volume following subcutaneous implantation and showed higher radiologic score (less bony destruction) after femoral implantation compared to those in a control group. These results suggest that rhBMP-2 inhibits rather than activates proliferation of human esophageal cancer cells which is mediated through activating the hippo signaling pathway. | - |
dc.language | English | - |
dc.publisher | NATURE PUBLISHING GROUP | - |
dc.title | RhBMP-2 Activates Hippo Signaling through RASSF1 in Esophageal Cancer Cells | - |
dc.type | Article | - |
dc.identifier.wosid | 000376737500001 | - |
dc.identifier.scopusid | 2-s2.0-84971329189 | - |
dc.type.rims | ART | - |
dc.citation.volume | 6 | - |
dc.citation.publicationname | SCIENTIFIC REPORTS | - |
dc.identifier.doi | 10.1038/srep26821 | - |
dc.contributor.localauthor | Park, Byung Hyun | - |
dc.contributor.nonIdAuthor | Kim, Soo Mi | - |
dc.contributor.nonIdAuthor | Ye, Shuai | - |
dc.contributor.nonIdAuthor | Rah, So-Young | - |
dc.contributor.nonIdAuthor | Wang, Hongen | - |
dc.contributor.nonIdAuthor | Kim, Jung-Ryul | - |
dc.contributor.nonIdAuthor | Kim, Seung Ho | - |
dc.contributor.nonIdAuthor | Jang, Kyu Yun | - |
dc.contributor.nonIdAuthor | Lee, Kwang-Bok | - |
dc.description.isOpenAccess | N | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordPlus | BONE MORPHOGENETIC PROTEIN-2 | - |
dc.subject.keywordPlus | TUMOR-SUPPRESSOR GENE | - |
dc.subject.keywordPlus | EPIGENETIC INACTIVATION | - |
dc.subject.keywordPlus | GASTRIC-CANCER | - |
dc.subject.keywordPlus | IN-VIVO | - |
dc.subject.keywordPlus | GROWTH | - |
dc.subject.keywordPlus | PATHWAY | - |
dc.subject.keywordPlus | DROSOPHILA | - |
dc.subject.keywordPlus | PROLIFERATION | - |
dc.subject.keywordPlus | CARCINOMA | - |
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