DC Field | Value | Language |
---|---|---|
dc.contributor.author | Chae, MR | ko |
dc.contributor.author | Park, BH | ko |
dc.contributor.author | Kim, JS | ko |
dc.contributor.author | Rho, HW | ko |
dc.contributor.author | Park, JW | ko |
dc.contributor.author | Kim, HR | ko |
dc.date.accessioned | 2024-03-22T06:04:25Z | - |
dc.date.available | 2024-03-22T06:04:25Z | - |
dc.date.created | 2024-03-21 | - |
dc.date.created | 2024-03-21 | - |
dc.date.issued | 2000 | - |
dc.identifier.citation | MICROBIOLOGY AND IMMUNOLOGY, v.44, no.5, pp.335 - 340 | - |
dc.identifier.issn | 0385-5600 | - |
dc.identifier.uri | http://hdl.handle.net/10203/318767 | - |
dc.description.abstract | Vibrio vulnificus infection has attracted special interest because of its high mortality. A strong clinical association exists between hepatic dysfunction and increased morbidity and mortality from V. vulnificus infection. In this study, the effect of C-reactive protein (CRP), a typical hepatogenic acute phase protein, on the lethality induced by V. vulnificus lipopolysaccharide (LPS) was investigated in galactosamine-sensitized mice. The pretreatment of CRP, in a dose of at least 2 mg/kg, 2 hr before the challenge of LPS completely protected mice against the lethality by V. vulnificus LPS, The elevation of serum tumor necrosis factor-alpha (TNF-alpha) induced by LPS administration was not affected by CRP pretreatment, However, the LPS- or TNF-alpha-induced hepatotoxicity was completely prevented by CRP, These results indicate that CRP does not prevent the synthesis, but prevents the hepatotoxic action of TNF-alpha. The possibility that impaired production of acute phase proteins in patients with pre-existing hepatic dysfunction may predispose the higher risk of V. vulnificus infection needs to be evaluated further. | - |
dc.language | English | - |
dc.publisher | CENTER ACADEMIC PUBL JAPAN | - |
dc.title | Protective effect of C-reactive protein against the lethality induced by Vibrio vulnificus lipopolysaccharide | - |
dc.type | Article | - |
dc.identifier.wosid | 000086971700001 | - |
dc.identifier.scopusid | 2-s2.0-0034044587 | - |
dc.type.rims | ART | - |
dc.citation.volume | 44 | - |
dc.citation.issue | 5 | - |
dc.citation.beginningpage | 335 | - |
dc.citation.endingpage | 340 | - |
dc.citation.publicationname | MICROBIOLOGY AND IMMUNOLOGY | - |
dc.identifier.doi | 10.1111/j.1348-0421.2000.tb02503.x | - |
dc.contributor.localauthor | Park, BH | - |
dc.contributor.nonIdAuthor | Chae, MR | - |
dc.contributor.nonIdAuthor | Kim, JS | - |
dc.contributor.nonIdAuthor | Rho, HW | - |
dc.contributor.nonIdAuthor | Park, JW | - |
dc.contributor.nonIdAuthor | Kim, HR | - |
dc.description.isOpenAccess | N | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | C-reactive protein | - |
dc.subject.keywordAuthor | Vibrio vulnificus | - |
dc.subject.keywordAuthor | lipopolysaccharide | - |
dc.subject.keywordAuthor | tumor necrosis factor-alpha | - |
dc.subject.keywordPlus | TUMOR-NECROSIS-FACTOR | - |
dc.subject.keywordPlus | GALACTOSAMINE-TREATED MICE | - |
dc.subject.keywordPlus | ACUTE-PHASE PROTEINS | - |
dc.subject.keywordPlus | FACTOR-ALPHA | - |
dc.subject.keywordPlus | ENDOTOXIN | - |
dc.subject.keywordPlus | PATHOGENESIS | - |
dc.subject.keywordPlus | SERUM | - |
dc.subject.keywordPlus | BLOOD | - |
dc.subject.keywordPlus | INFLAMMATION | - |
dc.subject.keywordPlus | EPIDEMIOLOGY | - |
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