Effect of xanthohumol on melanogenesis in B16 melanoma cells

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dc.contributor.authorKoo, Jeung-Hyunko
dc.contributor.authorKim, Hyoung Taeko
dc.contributor.authorYoon, Ha-Yongko
dc.contributor.authorKwon, Kang-Beomko
dc.contributor.authorChoi, Il-Whanko
dc.contributor.authorJung, Sung Hooko
dc.contributor.authorKim, Han-Ukko
dc.contributor.authorPark, Byung-Hyunko
dc.contributor.authorPark, Jin-Wooko
dc.date.accessioned2024-03-22T06:04:11Z-
dc.date.available2024-03-22T06:04:11Z-
dc.date.created2024-03-21-
dc.date.issued2008-06-
dc.identifier.citationEXPERIMENTAL AND MOLECULAR MEDICINE, v.40, no.3, pp.313 - 319-
dc.identifier.issn1226-3613-
dc.identifier.urihttp://hdl.handle.net/10203/318764-
dc.description.abstractXanthohumol (XH), the principal prenylflavonoid of the hop plant (Humulus lupulus L.), dose-dependently inhibited isobutylmethylxanthine (IBMX)-induced melanogenesis in B16 melanoma cells, with little cytotoxicity at the effective concentrations. Decreased melanin content was accompanied by reduced tyrosinase enzyme activity, protein and mRNA expression. The levels of tyrosinase-related protein 1 and 2 mRNAs were decreased by XH. XH also inhibited a-melanocyte stimulating hormone- or forskolin-induced increases in melanogenesis, suggesting an action on the cAMP-dependent melanogenic pathway. XH downregulated the protein and mRNA expression of microphthalmia-associated transcription factor (MITF), a master transcriptional regulator of key melanogenic enzymes. These results suggest that XH might act as a hypo-pigmenting agent through the downregulation of MITF in the cAMP-dependent melanogenic pathway.-
dc.languageEnglish-
dc.publisherNATURE PUBLISHING GROUP-
dc.titleEffect of xanthohumol on melanogenesis in B16 melanoma cells-
dc.typeArticle-
dc.identifier.wosid000257360800007-
dc.identifier.scopusid2-s2.0-46449104880-
dc.type.rimsART-
dc.citation.volume40-
dc.citation.issue3-
dc.citation.beginningpage313-
dc.citation.endingpage319-
dc.citation.publicationnameEXPERIMENTAL AND MOLECULAR MEDICINE-
dc.identifier.doi10.3858/emm.2008.40.3.313-
dc.contributor.localauthorPark, Byung-Hyun-
dc.contributor.nonIdAuthorKoo, Jeung-Hyun-
dc.contributor.nonIdAuthorKim, Hyoung Tae-
dc.contributor.nonIdAuthorYoon, Ha-Yong-
dc.contributor.nonIdAuthorKwon, Kang-Beom-
dc.contributor.nonIdAuthorChoi, Il-Whan-
dc.contributor.nonIdAuthorJung, Sung Hoo-
dc.contributor.nonIdAuthorKim, Han-Uk-
dc.contributor.nonIdAuthorPark, Jin-Woo-
dc.description.isOpenAccessN-
dc.type.journalArticleArticle-
dc.subject.keywordAuthorcell differentiation-
dc.subject.keywordAuthormelanins-
dc.subject.keywordAuthormelanocytes-
dc.subject.keywordAuthormicrophthalmia-associated transcription factor-
dc.subject.keywordAuthormonophenol monooxygenase-
dc.subject.keywordAuthorxanthohumol-
dc.subject.keywordPlusHOPS HUMULUS-LUPULUS-
dc.subject.keywordPlusSKIN PIGMENTATION-
dc.subject.keywordPlusIN-VITRO-
dc.subject.keywordPlusHUMAN MELANOCYTES-
dc.subject.keywordPlusTYROSINASE-
dc.subject.keywordPlusACTIVATION-
dc.subject.keywordPlusMITF-
dc.subject.keywordPlusTRANSCRIPTION-
dc.subject.keywordPlusSTIMULATION-
dc.subject.keywordPlusDERIVATIVES-
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