DC Field | Value | Language |
---|---|---|
dc.contributor.author | Koo, Jeung-Hyun | ko |
dc.contributor.author | Kim, Hyoung Tae | ko |
dc.contributor.author | Yoon, Ha-Yong | ko |
dc.contributor.author | Kwon, Kang-Beom | ko |
dc.contributor.author | Choi, Il-Whan | ko |
dc.contributor.author | Jung, Sung Hoo | ko |
dc.contributor.author | Kim, Han-Uk | ko |
dc.contributor.author | Park, Byung-Hyun | ko |
dc.contributor.author | Park, Jin-Woo | ko |
dc.date.accessioned | 2024-03-22T06:04:11Z | - |
dc.date.available | 2024-03-22T06:04:11Z | - |
dc.date.created | 2024-03-21 | - |
dc.date.issued | 2008-06 | - |
dc.identifier.citation | EXPERIMENTAL AND MOLECULAR MEDICINE, v.40, no.3, pp.313 - 319 | - |
dc.identifier.issn | 1226-3613 | - |
dc.identifier.uri | http://hdl.handle.net/10203/318764 | - |
dc.description.abstract | Xanthohumol (XH), the principal prenylflavonoid of the hop plant (Humulus lupulus L.), dose-dependently inhibited isobutylmethylxanthine (IBMX)-induced melanogenesis in B16 melanoma cells, with little cytotoxicity at the effective concentrations. Decreased melanin content was accompanied by reduced tyrosinase enzyme activity, protein and mRNA expression. The levels of tyrosinase-related protein 1 and 2 mRNAs were decreased by XH. XH also inhibited a-melanocyte stimulating hormone- or forskolin-induced increases in melanogenesis, suggesting an action on the cAMP-dependent melanogenic pathway. XH downregulated the protein and mRNA expression of microphthalmia-associated transcription factor (MITF), a master transcriptional regulator of key melanogenic enzymes. These results suggest that XH might act as a hypo-pigmenting agent through the downregulation of MITF in the cAMP-dependent melanogenic pathway. | - |
dc.language | English | - |
dc.publisher | NATURE PUBLISHING GROUP | - |
dc.title | Effect of xanthohumol on melanogenesis in B16 melanoma cells | - |
dc.type | Article | - |
dc.identifier.wosid | 000257360800007 | - |
dc.identifier.scopusid | 2-s2.0-46449104880 | - |
dc.type.rims | ART | - |
dc.citation.volume | 40 | - |
dc.citation.issue | 3 | - |
dc.citation.beginningpage | 313 | - |
dc.citation.endingpage | 319 | - |
dc.citation.publicationname | EXPERIMENTAL AND MOLECULAR MEDICINE | - |
dc.identifier.doi | 10.3858/emm.2008.40.3.313 | - |
dc.contributor.localauthor | Park, Byung-Hyun | - |
dc.contributor.nonIdAuthor | Koo, Jeung-Hyun | - |
dc.contributor.nonIdAuthor | Kim, Hyoung Tae | - |
dc.contributor.nonIdAuthor | Yoon, Ha-Yong | - |
dc.contributor.nonIdAuthor | Kwon, Kang-Beom | - |
dc.contributor.nonIdAuthor | Choi, Il-Whan | - |
dc.contributor.nonIdAuthor | Jung, Sung Hoo | - |
dc.contributor.nonIdAuthor | Kim, Han-Uk | - |
dc.contributor.nonIdAuthor | Park, Jin-Woo | - |
dc.description.isOpenAccess | N | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | cell differentiation | - |
dc.subject.keywordAuthor | melanins | - |
dc.subject.keywordAuthor | melanocytes | - |
dc.subject.keywordAuthor | microphthalmia-associated transcription factor | - |
dc.subject.keywordAuthor | monophenol monooxygenase | - |
dc.subject.keywordAuthor | xanthohumol | - |
dc.subject.keywordPlus | HOPS HUMULUS-LUPULUS | - |
dc.subject.keywordPlus | SKIN PIGMENTATION | - |
dc.subject.keywordPlus | IN-VITRO | - |
dc.subject.keywordPlus | HUMAN MELANOCYTES | - |
dc.subject.keywordPlus | TYROSINASE | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | MITF | - |
dc.subject.keywordPlus | TRANSCRIPTION | - |
dc.subject.keywordPlus | STIMULATION | - |
dc.subject.keywordPlus | DERIVATIVES | - |
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