DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lv, Na | ko |
dc.contributor.author | Song, Mi-Young | ko |
dc.contributor.author | Kim, Eun-Kyung | ko |
dc.contributor.author | Park, Jin-Woo | ko |
dc.contributor.author | Kwon, Kang-Beom | ko |
dc.contributor.author | Park, Byung-Hyun | ko |
dc.date.accessioned | 2024-03-22T06:03:58Z | - |
dc.date.available | 2024-03-22T06:03:58Z | - |
dc.date.created | 2024-03-21 | - |
dc.date.issued | 2008-07 | - |
dc.identifier.citation | MOLECULAR AND CELLULAR ENDOCRINOLOGY, v.289, no.1-2, pp.49 - 59 | - |
dc.identifier.issn | 0303-7207 | - |
dc.identifier.uri | http://hdl.handle.net/10203/318761 | - |
dc.description.abstract | Guggulsterone has been used to treat hyperlipidemia, arthritis, and obesity. Although its anti-inflammatory and anti-hyperlipidemic effects have been well documented, the effect of guggulsterone on pancreatic P cells is unknown. Therefore, in this study, the effect of guggulsterone on IL-1 beta-and IFN-gamma-induced beta-cell damage was investigated. Treatment of RINm5F (RIN) rat insulinoma cells with IL-1 beta and IFN-gamma induced cell damage, and this damage was well correlated with nitric oxide (NO) and prostaglandin E-2 (PGE(2)) production. However, guggulsterone completely prevented cytokines-mediated cytotoxicity, as well as NO and PGE(2) production, and these effects were correlated with reduced levels of the inducible form of NO synthase (iNOS) and cyclooxygenase-2 (COX-2) mRNA and protein expressions. The molecular mechanism by which guggulsterone inhibits iNOS and COX-2 gene expressions appeared to involve the inhibition of NF-kappa B activation. The cytoprotective effects of guggulsterone were also mediated through the suppression of the JAK/STAT pathway. Cells treated with the cytokines downregulated the protein level of SOCS-3, however pretreatment with guggulsterone attenuated this decrease. Additionally, in a second set of experiments in which rat islets were used, the findings regarding the beta-cell protective effects of guggulsterone were essentially the same as those observed when RIN cells were used; guggulsterone prevented cytokines-induced NO and PGE(2) production, iNOS and COX-2 expressions, JAK/STAT activation, NF-kappa B activation, downregulation of SOCS-3, and impairment of glucose-stimulated insulin secretion. Collectively, these results suggest that guggulsterone may be used to preserve functional beta-cell mass. (C) 2008 Elsevier Ireland Ltd. All rights reserved. | - |
dc.language | English | - |
dc.publisher | ELSEVIER IRELAND LTD | - |
dc.title | Guggulsterone, a plant sterol, inhibits NF-κB activation and protects pancreatic β cells from cytokine toxicity | - |
dc.type | Article | - |
dc.identifier.wosid | 000257841700007 | - |
dc.identifier.scopusid | 2-s2.0-45049087913 | - |
dc.type.rims | ART | - |
dc.citation.volume | 289 | - |
dc.citation.issue | 1-2 | - |
dc.citation.beginningpage | 49 | - |
dc.citation.endingpage | 59 | - |
dc.citation.publicationname | MOLECULAR AND CELLULAR ENDOCRINOLOGY | - |
dc.identifier.doi | 10.1016/j.mce.2008.02.001 | - |
dc.contributor.localauthor | Park, Byung-Hyun | - |
dc.contributor.nonIdAuthor | Lv, Na | - |
dc.contributor.nonIdAuthor | Song, Mi-Young | - |
dc.contributor.nonIdAuthor | Kim, Eun-Kyung | - |
dc.contributor.nonIdAuthor | Park, Jin-Woo | - |
dc.contributor.nonIdAuthor | Kwon, Kang-Beom | - |
dc.description.isOpenAccess | N | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | guggulsterone | - |
dc.subject.keywordAuthor | cytokine | - |
dc.subject.keywordAuthor | beta cells | - |
dc.subject.keywordAuthor | NF-kappa B | - |
dc.subject.keywordAuthor | STAT | - |
dc.subject.keywordAuthor | SOCS-3 | - |
dc.subject.keywordPlus | NITRIC-OXIDE SYNTHASE | - |
dc.subject.keywordPlus | FARNESOID-X-RECEPTOR | - |
dc.subject.keywordPlus | NATURAL-PRODUCT GUGGULSTERONE | - |
dc.subject.keywordPlus | JAK-STAT | - |
dc.subject.keywordPlus | MEDIATED TOXICITY | - |
dc.subject.keywordPlus | SIGNAL-TRANSDUCTION | - |
dc.subject.keywordPlus | INSULIN-SECRETION | - |
dc.subject.keywordPlus | HUMAN ISLETS | - |
dc.subject.keywordPlus | C-JUN | - |
dc.subject.keywordPlus | EXPRESSION | - |
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