DC Field | Value | Language |
---|---|---|
dc.contributor.author | Jin, Eunsook S. | ko |
dc.contributor.author | Park, Byang-Hyun | ko |
dc.contributor.author | Sherry, A. Dean | ko |
dc.contributor.author | Malloy, Craig R. | ko |
dc.date.accessioned | 2024-03-22T05:01:42Z | - |
dc.date.available | 2024-03-22T05:01:42Z | - |
dc.date.created | 2024-03-21 | - |
dc.date.created | 2024-03-21 | - |
dc.date.created | 2024-03-21 | - |
dc.date.issued | 2007-03 | - |
dc.identifier.citation | DIABETES, v.56, no.3, pp.777 - 785 | - |
dc.identifier.issn | 0012-1797 | - |
dc.identifier.uri | http://hdl.handle.net/10203/318704 | - |
dc.description.abstract | Sources of plasma glucose and glucose turnover were investigated in 8-week-old (pre-diabetic) and 13-week-old (diabetic) Zucker (fa/fa) rats after a 24-h fast. Intraperitoneal (H2O)-H-2 was administered and [3,4-C-13(2)]glucose and [U-C-13(3)]propionate were infused into conscious active rats. C-13 nuclear magnetic resonance analysis of monoacetone glucose derived from blood glucose indicated that glucose production was increased significantly in 8- and 13-week-old fa/fa rats compared with age-matched Zucker (+/+) rats, and hepatic glycogen was dramatically higher among fa/fa animals regardless of age. Glycogenolysis, essentially 0 in +/+ rats after a 24-h fast, was significant in fa/fa rats (11 +/- 6 and 17 +/- 7% of glucose production in 8- and 13-week-old rats, respectively), even after a 24-h fast. Tricarboxylic acid (TCA) cycle flux and efflux of carbon skeletons from the cycle (cataplerosis) were both significantly higher in fa/fa rats compared with controls, but net gluconeogenesis from the TCA cycle was not higher because products leaving the cycle were returned to the cycle via a pyruvate cycling pathway. Thus, pyruvate cycling flux increased in proportion to TCA cycle flux, leaving net gluconeogenesis unchanged in fa/fa animals compared with control animals. The distribution of H-2 in skeletal muscle glycogen suggested that at least a fraction of glucose molecules entering glycogen pass through phosphomannose isomerase. | - |
dc.language | English | - |
dc.publisher | AMER DIABETES ASSOC | - |
dc.title | Role of excess glycogenolysis in fasting hyperglycemia among pre-diabetic and diabetic Zucker (fa/fa) rats | - |
dc.type | Article | - |
dc.identifier.wosid | 000244827500027 | - |
dc.identifier.scopusid | 2-s2.0-33847394988 | - |
dc.type.rims | ART | - |
dc.citation.volume | 56 | - |
dc.citation.issue | 3 | - |
dc.citation.beginningpage | 777 | - |
dc.citation.endingpage | 785 | - |
dc.citation.publicationname | DIABETES | - |
dc.identifier.doi | 10.2337/db06-0717 | - |
dc.contributor.localauthor | Park, Byang-Hyun | - |
dc.contributor.nonIdAuthor | Jin, Eunsook S. | - |
dc.contributor.nonIdAuthor | Sherry, A. Dean | - |
dc.contributor.nonIdAuthor | Malloy, Craig R. | - |
dc.description.isOpenAccess | N | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordPlus | NUCLEAR-MAGNETIC-RESONANCE | - |
dc.subject.keywordPlus | ENDOGENOUS GLUCOSE-PRODUCTION | - |
dc.subject.keywordPlus | LIVER-GLYCOGEN | - |
dc.subject.keywordPlus | 3-DAY FAST | - |
dc.subject.keywordPlus | GLUCONEOGENESIS | - |
dc.subject.keywordPlus | MELLITUS | - |
dc.subject.keywordPlus | METABOLISM | - |
dc.subject.keywordPlus | HUMANS | - |
dc.subject.keywordPlus | CARBON | - |
dc.subject.keywordPlus | HEPATOCYTES | - |
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