DC Field | Value | Language |
---|---|---|
dc.contributor.author | Yang, Jeong-Yeh | ko |
dc.contributor.author | Koo, Jeung-Hyun | ko |
dc.contributor.author | Yoon, Ha-Yong | ko |
dc.contributor.author | Lee, Ju-Hyung | ko |
dc.contributor.author | Park, Byung-Hyun | ko |
dc.contributor.author | Kim, Jong-Suk | ko |
dc.contributor.author | Chi, Myung S. | ko |
dc.contributor.author | Park, Jin-Woo | ko |
dc.date.accessioned | 2024-03-22T05:01:24Z | - |
dc.date.available | 2024-03-22T05:01:24Z | - |
dc.date.created | 2024-03-21 | - |
dc.date.created | 2024-03-21 | - |
dc.date.issued | 2007-10 | - |
dc.identifier.citation | INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, v.20, no.4, pp.527 - 531 | - |
dc.identifier.issn | 1107-3756 | - |
dc.identifier.uri | http://hdl.handle.net/10203/318700 | - |
dc.description.abstract | Hypertriglyceridemia is an independent risk factor of cardiovascular diseases. It is caused by the imbalance between hepatic triglyceride production and peripheral removal. Lipoprotein lipase (LPL) plays a central role in the removal of plasma triglyceride. During the screening of possible anti-dyslipidemic drugs, we observed that scopoletin (6-metboxy-7-hydroxycoumarin) significantly increased LPL activity in adipocytes. Scopoletin increased LPL activity in culture medium of 3T3-L1 adipocytes in dose- and time-dependent manners. It did not release LPL from the adipocyte membrane and, instead, increased the LPL mRNA level, suggesting transcriptional control. Scopoletin also partially reversed tumor necrosis factor-alpha induced suppression of LPL activity. These results suggest the possible action of scopoletin as a facilitator of plasma triglyceride clearance. | - |
dc.language | English | - |
dc.publisher | PROFESSOR D A SPANDIDOS | - |
dc.title | Effect of scopoletin on lipoprotein lipase activity in 3T3-L1 adipocytes | - |
dc.type | Article | - |
dc.identifier.wosid | 000249797000014 | - |
dc.type.rims | ART | - |
dc.citation.volume | 20 | - |
dc.citation.issue | 4 | - |
dc.citation.beginningpage | 527 | - |
dc.citation.endingpage | 531 | - |
dc.citation.publicationname | INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE | - |
dc.contributor.localauthor | Park, Byung-Hyun | - |
dc.contributor.nonIdAuthor | Yang, Jeong-Yeh | - |
dc.contributor.nonIdAuthor | Koo, Jeung-Hyun | - |
dc.contributor.nonIdAuthor | Yoon, Ha-Yong | - |
dc.contributor.nonIdAuthor | Lee, Ju-Hyung | - |
dc.contributor.nonIdAuthor | Kim, Jong-Suk | - |
dc.contributor.nonIdAuthor | Chi, Myung S. | - |
dc.contributor.nonIdAuthor | Park, Jin-Woo | - |
dc.description.isOpenAccess | N | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordPlus | TUMOR-NECROSIS-FACTOR | - |
dc.subject.keywordPlus | ACTIVATOR NO-1886 | - |
dc.subject.keywordPlus | CELLS | - |
dc.subject.keywordPlus | HYPERTRIGLYCERIDEMIA | - |
dc.subject.keywordPlus | ATHEROSCLEROSIS | - |
dc.subject.keywordPlus | SECRETION | - |
dc.subject.keywordPlus | GLYCOSYLATION | - |
dc.subject.keywordPlus | DIMERIZATION | - |
dc.subject.keywordPlus | CONSTITUENT | - |
dc.subject.keywordPlus | RATS | - |
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