DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kwon, Kang Beom | ko |
dc.contributor.author | Kim, Eun Kyung | ko |
dc.contributor.author | Han, Mi Jeong | ko |
dc.contributor.author | Shin, Byung Cheul | ko |
dc.contributor.author | Park, Yong Kweon | ko |
dc.contributor.author | Kim, Kang San | ko |
dc.contributor.author | Lee, Young Rae | ko |
dc.contributor.author | Park, Jin Woo | ko |
dc.contributor.author | Park, Byung Hyun | ko |
dc.contributor.author | Ryu, Do Gon | ko |
dc.date.accessioned | 2024-03-22T03:01:02Z | - |
dc.date.available | 2024-03-22T03:01:02Z | - |
dc.date.created | 2024-03-21 | - |
dc.date.created | 2024-03-21 | - |
dc.date.created | 2024-03-21 | - |
dc.date.issued | 2006-06 | - |
dc.identifier.citation | BIOLOGICAL PHARMACEUTICAL BULLETIN, v.29, no.6, pp.1082 - 1086 | - |
dc.identifier.issn | 0918-6158 | - |
dc.identifier.uri | http://hdl.handle.net/10203/318663 | - |
dc.description.abstract | Radix Paeoniae Alba has been used as a constituent of herbal medicine prescriptions for the treatment of inflammation, cancer, and other diseases. The aim of this study was to investigate the mechanism of Radix Paeoniae Alba extract (RPAE)-induced apoptosis in HL-60 leukemic cells. We observed that RPAE induced apoptotic changes in a dose-dependent manner, which was confirmed by DNA fragmentation and poly-(ADP-ribose) polymerase (PARP) cleavage. We also found release of cytochrome c from mitochondria to the cytosol in RPAE-treated HL-60 cells. The caspases, caspase-9 and -3, but not caspase-8, were found to be activated in response to RPAE treatment, and the caspase-3 inhibitor, Ac-DEVD-CHO, and the caspase-9 inhibitor, z-LEHD-FMK, but not the caspase-8 inhibitor, z-IETD-FMK, attenuated RPAE-induced DNA fragmentation and PARP cleavage. These results suggest that RPAE-induced apoptosis is stimulated by the release of cytochrome c to the cytosol, by procaspase-9 processing, and via a caspase-3 dependent mechanism. | - |
dc.language | English | - |
dc.publisher | PHARMACEUTICAL SOC JAPAN | - |
dc.title | Induction of apoptosis by Radix Paeoniae Alba extract through cytochrome c release and the activations of caspase-9 and caspase-3 in HL-60 cells | - |
dc.type | Article | - |
dc.identifier.wosid | 000238470500002 | - |
dc.identifier.scopusid | 2-s2.0-33744943785 | - |
dc.type.rims | ART | - |
dc.citation.volume | 29 | - |
dc.citation.issue | 6 | - |
dc.citation.beginningpage | 1082 | - |
dc.citation.endingpage | 1086 | - |
dc.citation.publicationname | BIOLOGICAL PHARMACEUTICAL BULLETIN | - |
dc.identifier.doi | 10.1248/bpb.29.1082 | - |
dc.contributor.localauthor | Park, Byung Hyun | - |
dc.contributor.nonIdAuthor | Kwon, Kang Beom | - |
dc.contributor.nonIdAuthor | Kim, Eun Kyung | - |
dc.contributor.nonIdAuthor | Han, Mi Jeong | - |
dc.contributor.nonIdAuthor | Shin, Byung Cheul | - |
dc.contributor.nonIdAuthor | Park, Yong Kweon | - |
dc.contributor.nonIdAuthor | Kim, Kang San | - |
dc.contributor.nonIdAuthor | Lee, Young Rae | - |
dc.contributor.nonIdAuthor | Park, Jin Woo | - |
dc.contributor.nonIdAuthor | Ryu, Do Gon | - |
dc.description.isOpenAccess | N | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | Radix Paeoniae Alba | - |
dc.subject.keywordAuthor | apoptosis | - |
dc.subject.keywordAuthor | HL-60 leukemic cell | - |
dc.subject.keywordPlus | IMMUNOLOGICAL ACTIVITIES | - |
dc.subject.keywordPlus | ACIDIC POLYSACCHARIDE | - |
dc.subject.keywordPlus | MEDIATED APOPTOSIS | - |
dc.subject.keywordPlus | SIGNALING PATHWAYS | - |
dc.subject.keywordPlus | DNA FRAGMENTATION | - |
dc.subject.keywordPlus | PEONIA-LACTIFLORA | - |
dc.subject.keywordPlus | PROTEASE | - |
dc.subject.keywordPlus | SYSTEM | - |
dc.subject.keywordPlus | DEATH | - |
dc.subject.keywordPlus | ROOT | - |
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