DC Field | Value | Language |
---|---|---|
dc.contributor.author | Bae, Ui-Jin | ko |
dc.contributor.author | Choi, Eun-Kyung | ko |
dc.contributor.author | Oh, Mi-Ra | ko |
dc.contributor.author | Jung, Su-Jin | ko |
dc.contributor.author | Park, Joon | ko |
dc.contributor.author | Jung, Tae-Sung | ko |
dc.contributor.author | Park, Tae-Sun | ko |
dc.contributor.author | Chae, Soo-Wan | ko |
dc.contributor.author | Park, Byung-Hyun | ko |
dc.date.accessioned | 2024-03-21T23:00:16Z | - |
dc.date.available | 2024-03-21T23:00:16Z | - |
dc.date.created | 2024-03-21 | - |
dc.date.issued | 2016 | - |
dc.identifier.citation | AMERICAN JOURNAL OF CHINESE MEDICINE, v.44, no.8, pp.1627 - 1638 | - |
dc.identifier.issn | 0192-415X | - |
dc.identifier.uri | http://hdl.handle.net/10203/318612 | - |
dc.description.abstract | The prevention and management of type 2 diabetes mellitus has become a major global public health challenge. Decursin, an active compound of Angelica gigas Nakai roots, was recently reported to have a glucose-lowering activity. However, the antidiabetic effect of Angelica gigas Nakai extract (AGNE) has not yet been investigated. We evaluated the effects of AGNE on glucose homeostasis in type 2 diabetic mice and investigated the underlying mechanism by which AGNE acts. Male C57BL/KsJ-db/db mice were treated with either AGNE (10 mg/kg, 20 mg/kg, and 40 mg/kg) or metformin (100 mg/kg) for 8 weeks. AGNE supplementation (20 and 40 mg/kg) significantly decreased fasting glucose and insulin levels, decreased the areas under the curve of glucose in oral glucose tolerance tolerance tests, and improved homeostatic model assessment-insulin resistant (HOMA-IR) scores. AGNE also ameliorated hepatic steatosis, hyperlipidemia, and hypercholesterolemia. Mechanistic studies suggested that the glucose-lowering effect of AGNE was mediated by the activation of AMP activated protein kinase, Akt, and glycogen synthase kinase-3 beta. AGNE can potentially improve hyperglycemia and hepatic steatosis in patients with type 2 diabetes. | - |
dc.language | English | - |
dc.publisher | WORLD SCIENTIFIC PUBL CO PTE LTD | - |
dc.title | Angelica gigas Ameliorates Hyperglycemia and Hepatic Steatosis in C57BL/KsJ-db/db Mice via Activation of AMP-Activated Protein Kinase Signaling Pathway | - |
dc.type | Article | - |
dc.identifier.wosid | 000390380900007 | - |
dc.identifier.scopusid | 2-s2.0-84995772000 | - |
dc.type.rims | ART | - |
dc.citation.volume | 44 | - |
dc.citation.issue | 8 | - |
dc.citation.beginningpage | 1627 | - |
dc.citation.endingpage | 1638 | - |
dc.citation.publicationname | AMERICAN JOURNAL OF CHINESE MEDICINE | - |
dc.identifier.doi | 10.1142/S0192415X16500919 | - |
dc.contributor.localauthor | Park, Byung-Hyun | - |
dc.contributor.nonIdAuthor | Bae, Ui-Jin | - |
dc.contributor.nonIdAuthor | Choi, Eun-Kyung | - |
dc.contributor.nonIdAuthor | Oh, Mi-Ra | - |
dc.contributor.nonIdAuthor | Jung, Su-Jin | - |
dc.contributor.nonIdAuthor | Park, Joon | - |
dc.contributor.nonIdAuthor | Jung, Tae-Sung | - |
dc.contributor.nonIdAuthor | Park, Tae-Sun | - |
dc.contributor.nonIdAuthor | Chae, Soo-Wan | - |
dc.description.isOpenAccess | N | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | Angelica gigas Nakai | - |
dc.subject.keywordAuthor | Insulin Resistance | - |
dc.subject.keywordAuthor | AMPK | - |
dc.subject.keywordAuthor | Hepatic Steatosis | - |
dc.subject.keywordAuthor | Hypoglycemic Effects | - |
dc.subject.keywordPlus | DIABETES-MELLITUS | - |
dc.subject.keywordPlus | DECURSIN | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | MECHANISM | - |
dc.subject.keywordPlus | CELLS | - |
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