DC Field | Value | Language |
---|---|---|
dc.contributor.advisor | Kang, Sung-Ho | - |
dc.contributor.advisor | 강성호 | - |
dc.contributor.author | Lee, Jung-Hwa | - |
dc.contributor.author | 이정화 | - |
dc.date.accessioned | 2011-12-13T04:46:42Z | - |
dc.date.available | 2011-12-13T04:46:42Z | - |
dc.date.issued | 1998 | - |
dc.identifier.uri | http://library.kaist.ac.kr/search/detail/view.do?bibCtrlNo=135276&flag=dissertation | - |
dc.identifier.uri | http://hdl.handle.net/10203/31789 | - |
dc.description | 학위논문(석사) - 한국과학기술원 : 화학과, 1998.2, [ ii, 36 p. ] | - |
dc.description.abstract | Organomercurials, which was generated by intra- and inter-molecular mercury-promoted electrophilic additions, have been reductively demercurated in situ efficiently using sodium borohydride in the presence of triethylborane at low temperature. The results of reductive demercuration under the conditions developed by us are described and compared with those under the best known method using sodium borohydride in the presence of phase transfer catalyst.12 Under our conditions, the frequently accompanying side reactions such as reductive elimination and oxidative demercuration have not been detected. For the synthesis of epoxy amino acid 13 as the key component of LB-7116, the key intermediate 49 has been synthesized from D-glucosamine hydrochloride. Conversion of 38 into cyanide 28 was unsuccessful. Alternatively, alcohol 45 was prepared from D-glucosamine over 11 steps. Alcohol 45 was sequentially converted into diacetonide, monoacetonide, tosylate and cyanide, of which the hydrolysis to carboxylic acid is in progress. | eng |
dc.language | eng | - |
dc.publisher | 한국과학기술원 | - |
dc.subject | HIV-1 protease inhibitor | - |
dc.subject | Organomercurials | - |
dc.subject | Reductive demercuration | - |
dc.subject | Epoxy amino acid | - |
dc.subject | 에폭시 아미노 카르복시산 | - |
dc.subject | HIV 치료제 | - |
dc.subject | 유기수은 화합물 | - |
dc.subject | 탈수은화 반응 | - |
dc.title | Reductive demercuration of organomercurials | - |
dc.title.alternative | 유기수은 화합물의 효율적인 탈수은화 반응과 유망한 HIV 치료제의 핵심성분인 에폭시 아미노 카르복시산의 합성에 관한 연구 | - |
dc.type | Thesis(Master) | - |
dc.identifier.CNRN | 135276/325007 | - |
dc.description.department | 한국과학기술원 : 화학과, | - |
dc.identifier.uid | 000963483 | - |
dc.contributor.localauthor | Kang, Sung-Ho | - |
dc.contributor.localauthor | 강성호 | - |
dc.title.subtitle | a synthetic study on epoxy amino carboxylic acid as the key component of a HIV-1 protease inhibitor | - |
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