Mitochondrial nucleic acids in innate immunity and beyond

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dc.contributor.authorYoon, Jiminko
dc.contributor.authorKim, Sujinko
dc.contributor.authorLee, Mihyeko
dc.contributor.authorKim, Yoosikko
dc.date.accessioned2024-01-10T05:03:37Z-
dc.date.available2024-01-10T05:03:37Z-
dc.date.created2023-12-18-
dc.date.issued2023-12-
dc.identifier.citationEXPERIMENTAL AND MOLECULAR MEDICINE, v.55, no.12, pp.2508 - 2518-
dc.identifier.issn1226-3613-
dc.identifier.urihttp://hdl.handle.net/10203/317632-
dc.description.abstractMitochondria participate in a wide range of cellular processes. One essential function of mitochondria is to be a platform for antiviral signaling proteins during the innate immune response to viral infection. Recently, studies have revealed that mitochondrion-derived DNAs and RNAs are recognized as non-self molecules and act as immunogenic ligands. More importantly, the cytosolic release of these mitochondrial nucleic acids (mt-NAs) is closely associated with the pathogenesis of human diseases accompanying aberrant immune activation. The release of mitochondrial DNAs (mtDNAs) via BAX/BAK activation and/or VDAC1 oligomerization activates the innate immune response and inflammasome assembly. In addition, mitochondrial double-stranded RNAs (mt-dsRNAs) are sensed by pattern recognition receptors in the cytosol to induce type I interferon expression and initiate apoptotic programs. Notably, these cytosolic mt-NAs also mediate adipocyte differentiation and contribute to mitogenesis and mitochondrial thermogenesis. In this review, we summarize recent studies of innate immune signaling pathways regulated by mt-NAs, human diseases associated with mt-NAs, and the emerging physiological roles of mt-NAs. Mitochondrial nucleic acids (mt-NAs) play a crucial role in activating various innate immune signaling pathways and are associated with numerous human diseases. Downregulation of mt-NAs or their downstream receptors often alleviates interferon signature. Recent studies reveal that mt-NAs can also serve as key mediators of signaling between mitochondria and the nucleus, thereby contributing to cell physiology. In particular, studies have shown that mt-NAs can stimulate beige adipocyte development in young mice, which has potential therapeutic implications for obesity and insulin resistance. Understanding the multifaceted roles of mt-NAs will provide potential therapeutic strategies for mt-NA-mediated immune signaling regulation in pathophysiology.This summary was initially drafted using artificial intelligence, then revised and fact-checked by the author.-
dc.languageEnglish-
dc.publisherSPRINGERNATURE-
dc.titleMitochondrial nucleic acids in innate immunity and beyond-
dc.typeArticle-
dc.identifier.wosid001111472700006-
dc.identifier.scopusid2-s2.0-85178033752-
dc.type.rimsART-
dc.citation.volume55-
dc.citation.issue12-
dc.citation.beginningpage2508-
dc.citation.endingpage2518-
dc.citation.publicationnameEXPERIMENTAL AND MOLECULAR MEDICINE-
dc.identifier.doi10.1038/s12276-023-01121-x-
dc.identifier.kciidART003037469-
dc.contributor.localauthorKim, Yoosik-
dc.contributor.nonIdAuthorLee, Mihye-
dc.description.isOpenAccessN-
dc.type.journalArticleReview-
dc.subject.keywordPlusDOUBLE-STRANDED-RNA-
dc.subject.keywordPlusPERMEABILITY TRANSITION-
dc.subject.keywordPlusDNA-
dc.subject.keywordPlusINFLAMMATION-
dc.subject.keywordPlusRELEASE-
dc.subject.keywordPlusPROTEIN-
dc.subject.keywordPlusSTRESS-
dc.subject.keywordPlusTRANSCRIPTION-
dc.subject.keywordPlusMECHANISMS-
dc.subject.keywordPlusACTIVATE-
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