DC Field | Value | Language |
---|---|---|
dc.contributor.author | Hong, Jungwoo | ko |
dc.contributor.author | Lee, Wonchul | ko |
dc.contributor.author | Lee, Hee-Seung | ko |
dc.date.accessioned | 2024-01-02T08:00:36Z | - |
dc.date.available | 2024-01-02T08:00:36Z | - |
dc.date.created | 2023-11-10 | - |
dc.date.created | 2023-11-10 | - |
dc.date.created | 2023-11-10 | - |
dc.date.issued | 2023-12 | - |
dc.identifier.citation | BULLETIN OF THE KOREAN CHEMICAL SOCIETY, v.44, no.12, pp.1034 - 1039 | - |
dc.identifier.issn | 0253-2964 | - |
dc.identifier.uri | http://hdl.handle.net/10203/317205 | - |
dc.description.abstract | We present an optimized method for the stereoselective synthesis of five-membered alicyclic and heterocyclic trans-β-amino acid derivatives. The process involves a reductive amination of β-keto esters using chiral auxiliary amines, with formic acid acting as a facilitator for rapid, diastereoselective reductions under gentle conditions. Our approach notably enhances isolated yields and permits the scalable production of trans-2-aminocyclopentanecarboxylic acid (trans-ACPC), 4-aminopyrrolidine-3-carboxylic acid (trans-APC), 4-aminotetrahydrofuran-3-carboxylic acid (trans-ATFC), and 4-aminotetrahydrothiophene-3-carboxylic acid (trans-ATTC) building blocks. | - |
dc.language | English | - |
dc.publisher | WILEY-V C H VERLAG GMBH | - |
dc.title | Optimized stereoselective and scalable synthesis of five-membered cyclic trans-β-amino acid building blocks via reductive amination | - |
dc.type | Article | - |
dc.identifier.wosid | 001093236900001 | - |
dc.identifier.scopusid | 2-s2.0-85175434140 | - |
dc.type.rims | ART | - |
dc.citation.volume | 44 | - |
dc.citation.issue | 12 | - |
dc.citation.beginningpage | 1034 | - |
dc.citation.endingpage | 1039 | - |
dc.citation.publicationname | BULLETIN OF THE KOREAN CHEMICAL SOCIETY | - |
dc.identifier.doi | 10.1002/bkcs.12786 | - |
dc.identifier.kciid | ART003025349 | - |
dc.contributor.localauthor | Lee, Hee-Seung | - |
dc.contributor.nonIdAuthor | Lee, Wonchul | - |
dc.description.isOpenAccess | N | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | scalable synthesis | - |
dc.subject.keywordAuthor | stereoselective synthesis | - |
dc.subject.keywordAuthor | beta-amino acid | - |
dc.subject.keywordAuthor | mild condition | - |
dc.subject.keywordAuthor | reductive amination | - |
dc.subject.keywordPlus | EFFICIENT ROUTE | - |
dc.subject.keywordPlus | ENANTIOMER | - |
dc.subject.keywordPlus | PEPTIDES | - |
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