Measurement of CSF pulsation in Parkinson’s disease patients using EPI-based fMRI data

Abstract

The fMRI dataset for Parkinson’s disease with mild cognitive impairment (PD-MCI) was studied using a recently-proposed method of simultaneous CSF pulsation and BOLD activity imaging. The PD group was classified to dementia (PDD) high-risk and low-risk groups. The CSF pulsation of both PDD high-risk and low-risk groups was higher than that of healthy control. Opposite to the tendency of CSF pulsation, coefficient of variation of CSF pulsation was reduced in PD group compared to healthy control. These results indicate association of CSF pulsation with brain waste clearance in these patients, which requires further investigations for elucidation.