DC Field | Value | Language |
---|---|---|
dc.contributor.author | Cha, Jeong Hyeon | ko |
dc.contributor.author | Kim, Eunsu | ko |
dc.contributor.author | Lee, Hyeong Ji | ko |
dc.contributor.author | Lee, Young-Ho | ko |
dc.contributor.author | Lee, Jeonghyun | ko |
dc.contributor.author | Kim, Eunha | ko |
dc.contributor.author | Kim, Chan Hyuk | ko |
dc.date.accessioned | 2023-12-05T07:00:26Z | - |
dc.date.available | 2023-12-05T07:00:26Z | - |
dc.date.created | 2023-07-03 | - |
dc.date.issued | 2023-06 | - |
dc.identifier.citation | JOURNAL OF MEDICINAL CHEMISTRY, v.66, no.12, pp.7804 - 7812 | - |
dc.identifier.issn | 0022-2623 | - |
dc.identifier.uri | http://hdl.handle.net/10203/315731 | - |
dc.description.abstract | T cells expressing chimeric antigen receptors (CAR-Tcells) haveshown unprecedented clinical responses against hematological malignancies.However, some patients relapse after CAR-T cell therapy due to antigen-negativeescape variants. Additionally, CAR-T cell therapies showed limitedclinical efficacy in solid tumors with high antigen heterogeneity.To overcome this, we metabolically labeled the glycans on cancer cellsto redirect CAR-T cell cytotoxicity regardless of the endogenous antigenexpression status of the cancer cells. We found that modifying cancercells with N-azidoacetylmannosamine and bicyclo[6.1.0]non-4-yne-fluoresceinisothiocyanate can elicit selective and durable cytotoxicity of anti-FITCCAR-T cells. Furthermore, we demonstrated that dinitrophenyl-conjugatedsialic acid (Sia-DNP) generated DNP-modified glycans on cancer cellsin situ that could be effectively targeted by anti-DNP CAR-T cellsto eradicate established tumors in xenograft models. Our study illustratesthat metabolic glycan labeling using unnatural sugars can be combinedwith CAR-T cell therapy to provide novel cancer immunotherapy forsolid tumors that lack viable target antigens. | - |
dc.language | English | - |
dc.publisher | AMER CHEMICAL SOC | - |
dc.title | Redirection of CAR-T Cell Cytotoxicity Using Metabolic Glycan Labeling with Unnatural Sugars | - |
dc.type | Article | - |
dc.identifier.wosid | 001010258900001 | - |
dc.identifier.scopusid | 2-s2.0-85163492572 | - |
dc.type.rims | ART | - |
dc.citation.volume | 66 | - |
dc.citation.issue | 12 | - |
dc.citation.beginningpage | 7804 | - |
dc.citation.endingpage | 7812 | - |
dc.citation.publicationname | JOURNAL OF MEDICINAL CHEMISTRY | - |
dc.identifier.doi | 10.1021/acs.jmedchem.3c00048 | - |
dc.contributor.localauthor | Kim, Chan Hyuk | - |
dc.contributor.nonIdAuthor | Kim, Eunsu | - |
dc.contributor.nonIdAuthor | Lee, Hyeong Ji | - |
dc.contributor.nonIdAuthor | Lee, Young-Ho | - |
dc.contributor.nonIdAuthor | Lee, Jeonghyun | - |
dc.contributor.nonIdAuthor | Kim, Eunha | - |
dc.description.isOpenAccess | N | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordPlus | SIALIC-ACID | - |
dc.subject.keywordPlus | IMMUNOTHERAPY | - |
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