DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Yong Chan | ko |
dc.contributor.author | Nam, Heejin | ko |
dc.contributor.author | Choi, Jun Yong | ko |
dc.contributor.author | Shin, Eui-Cheol | ko |
dc.contributor.author | Choi, Young Hwa | ko |
dc.date.accessioned | 2023-12-04T06:02:16Z | - |
dc.date.available | 2023-12-04T06:02:16Z | - |
dc.date.created | 2023-12-04 | - |
dc.date.issued | 2023-10 | - |
dc.identifier.citation | JOURNAL OF INFECTION AND PUBLIC HEALTH, v.16, no.10, pp.1643 - 1649 | - |
dc.identifier.issn | 1876-0341 | - |
dc.identifier.uri | http://hdl.handle.net/10203/315665 | - |
dc.description.abstract | Background: Despite the low measles antibody positivity rate among young healthcare workers (HCWs) who have previously received two doses of a measles-containing vaccine (MCV), whether an additional dose of MCV acts as a booster remains unknown. Thus, we aimed to evaluate the immune responses to a third dose of MCV in young HCWs.Methods: Hospital-wide measles seroprevalence was assessed using enzyme-linked immunosorbent assay (ELISA). The immunogenicity of a third dose of MCV was determined in young seronegative HCWs (born between 1986 and 1997) who had previously received a two-dose measles vaccination.Results: A total of 3033 (92.6%) HCWs had anti-measles immunoglobulin G. The lowest seropositivity rate was observed in HCWs aged 20-24 years (87.7%). In this group, HCWs who received a third dose of MCV had higher seropositivity than those who received a second dose (89.5% vs. 75.4%). A third dose of MCV was administered to 18 HCWs who did not have anti-measles IgG despite two doses. Neutralizing antibody titers increased significantly 4 weeks after the third vaccination. Although neutralizing antibody titers decreased 1 year post vaccination, 17 (94.4%) HCWs had medium (121-900 mIU/mL) or high (> 900 mIU/mL) levels. Furthermore, the third dose of MCV increased the measles virus-specific T-cell effector function.Conclusions: The third dose of MCV induced a strong immune response against measles in young seronegative HCWs who had previously received a two-dose measles vaccination. | - |
dc.language | English | - |
dc.publisher | ELSEVIER SCIENCE LONDON | - |
dc.title | The third dose of measles-containing vaccine induces robust immune responses against measles in young seronegative healthcare workers who had previous two-dose measles vaccination | - |
dc.type | Article | - |
dc.identifier.wosid | 001099765600001 | - |
dc.identifier.scopusid | 2-s2.0-85168361854 | - |
dc.type.rims | ART | - |
dc.citation.volume | 16 | - |
dc.citation.issue | 10 | - |
dc.citation.beginningpage | 1643 | - |
dc.citation.endingpage | 1649 | - |
dc.citation.publicationname | JOURNAL OF INFECTION AND PUBLIC HEALTH | - |
dc.identifier.doi | 10.1016/j.jiph.2023.08.002 | - |
dc.contributor.localauthor | Shin, Eui-Cheol | - |
dc.contributor.nonIdAuthor | Kim, Yong Chan | - |
dc.contributor.nonIdAuthor | Nam, Heejin | - |
dc.contributor.nonIdAuthor | Choi, Jun Yong | - |
dc.contributor.nonIdAuthor | Choi, Young Hwa | - |
dc.description.isOpenAccess | N | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | Measles | - |
dc.subject.keywordAuthor | Seroprevalence | - |
dc.subject.keywordAuthor | Measles vaccine | - |
dc.subject.keywordAuthor | Immunogenicity | - |
dc.subject.keywordAuthor | Safety | - |
dc.subject.keywordPlus | RUBELLA VACCINE | - |
dc.subject.keywordPlus | MMR-VACCINE | - |
dc.subject.keywordPlus | IMMUNOGLOBULIN-G | - |
dc.subject.keywordPlus | ANTIBODY-LEVELS | - |
dc.subject.keywordPlus | MUMPS | - |
dc.subject.keywordPlus | SEROPREVALENCE | - |
dc.subject.keywordPlus | ELIMINATION | - |
dc.subject.keywordPlus | OUTBREAK | - |
dc.subject.keywordPlus | AVIDITY | - |
dc.subject.keywordPlus | KOREA | - |
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