Bioelectrochemical Interfaces: Bridging Digital and Biological Systems

Abstract

During the last few decades, electronic devices for recording and modulating electrical signals in biological systems have been applied to treat diseases and study biological systems. To further advance the communication between digital and biological systems, however, we need to consider biochemical signals, which affectthe physiology and pathology ofbiological systems in a complex way. In this talk, I will introduce bioelectrochemical interfaces thatcan modulate biochemical signals with digital inputs. Central to these interfaces is the use of biomimetic nanocatalysts for the electrochemical generation of chemical signals. I have demonstrated that these interfaces can be integrated into a wide range of biomaterials, including orthopedic implants and cardiovascular stents, to control cellular signaling. Recently, I extended this approach to develop neural probes capable of electrochemically producing gaseous neurotransmitters in the brain. These probes enable the study of how these chemical signals affect neural signaling and animal behavior. I envision that my research in bioelectrochemical interfaces will advance our understanding and control over biological systems.