DC Field | Value | Language |
---|---|---|
dc.contributor.author | Shin, Hyunjae | ko |
dc.contributor.author | Lee, Ha Seok | ko |
dc.contributor.author | Noh, Ji Yun | ko |
dc.contributor.author | Koh, June-Young | ko |
dc.contributor.author | Kim, So-Young | ko |
dc.contributor.author | Park, Jeayeon | ko |
dc.contributor.author | Chung, Sung Won | ko |
dc.contributor.author | Hur, Moon Haeng | ko |
dc.contributor.author | Park, Min Kyung | ko |
dc.contributor.author | Lee, Yun Bin | ko |
dc.contributor.author | Kim, Yoon Jun | ko |
dc.contributor.author | Yoon, Jung-Hwan | ko |
dc.contributor.author | Ko, Jae-Hoon | ko |
dc.contributor.author | Peck, Kyong Ran | ko |
dc.contributor.author | Song, Joon Young | ko |
dc.contributor.author | Shin, Eui-Cheol | ko |
dc.contributor.author | Lee, Jeong-Hoon | ko |
dc.date.accessioned | 2023-11-25T08:00:29Z | - |
dc.date.available | 2023-11-25T08:00:29Z | - |
dc.date.created | 2023-11-25 | - |
dc.date.created | 2023-11-25 | - |
dc.date.created | 2023-11-25 | - |
dc.date.created | 2023-11-25 | - |
dc.date.issued | 2023-10 | - |
dc.identifier.citation | IMMUNE NETWORK, v.23, no.5, pp.1 - 15 | - |
dc.identifier.issn | 1598-2629 | - |
dc.identifier.uri | http://hdl.handle.net/10203/315159 | - |
dc.description.abstract | Coronavirus disease 2019 (COVID-19) vaccination may non-specifically alter the host immune system. This study aimed to evaluate the effect of COVID-19 vaccination on hepatitis B surface Ag (HBsAg) titer and host immunity in chronic hepatitis B (CHB) patients. Consecutive 2,797 CHB patients who had serial HBsAg measurements during antiviral treatment were included in this study. Changes in the HBsAg levels after COVID-19 vaccination were analyzed. The dynamics of NK cells following COVID-19 vaccination were also examined using serial blood samples collected prospectively from 25 healthy volunteers. Vaccinated CHB patients (n=2,329) had significantly lower HBsAg levels 1–30 days post-vaccination compared to baseline (median, −21.4 IU/ml from baseline), but the levels reverted to baseline by 91–180 days (median, −3.8 IU/ml). The velocity of the HBsAg decline was transiently accelerated within 30 days after vaccination (median velocity: −0.06, −0.39, and −0.04 log10 IU/ml/year in pre-vaccination period, days 1–30, and days 31–90, respectively). In contrast, unvaccinated patients (n=468) had no change in HBsAg levels. Flow cytometric analysis showed that the frequency of NK cells expressing NKG2A, an NK inhibitory receptor, significantly decreased within 7 days after the first dose of COVID-19 vaccine (median, −13.1% from baseline; p<0.001). The decrease in the frequency of NKG2A+ NK cells was observed in the CD56dimCD16+ NK cell population regardless of type of COVID-19 vaccine. COVID-19 vaccination leads to a rapid, transient decline in HBsAg titer and a decrease in the frequency of NKG2A+ NK cells. | - |
dc.language | English | - |
dc.publisher | KOREA ASSOC IMMUNOLOGISTS | - |
dc.title | COVID-19 Vaccination Alters NK Cell Dynamics and Transiently Reduces HBsAg Titers Among Patients With Chronic Hepatitis B | - |
dc.type | Article | - |
dc.identifier.wosid | 001142481300004 | - |
dc.identifier.scopusid | 2-s2.0-85177476489 | - |
dc.type.rims | ART | - |
dc.citation.volume | 23 | - |
dc.citation.issue | 5 | - |
dc.citation.beginningpage | 1 | - |
dc.citation.endingpage | 15 | - |
dc.citation.publicationname | IMMUNE NETWORK | - |
dc.identifier.doi | 10.4110/in.2023.23.e39 | - |
dc.identifier.kciid | ART003013783 | - |
dc.contributor.localauthor | Shin, Eui-Cheol | - |
dc.contributor.nonIdAuthor | Shin, Hyunjae | - |
dc.contributor.nonIdAuthor | Noh, Ji Yun | - |
dc.contributor.nonIdAuthor | Park, Jeayeon | - |
dc.contributor.nonIdAuthor | Chung, Sung Won | - |
dc.contributor.nonIdAuthor | Hur, Moon Haeng | - |
dc.contributor.nonIdAuthor | Park, Min Kyung | - |
dc.contributor.nonIdAuthor | Lee, Yun Bin | - |
dc.contributor.nonIdAuthor | Kim, Yoon Jun | - |
dc.contributor.nonIdAuthor | Yoon, Jung-Hwan | - |
dc.contributor.nonIdAuthor | Ko, Jae-Hoon | - |
dc.contributor.nonIdAuthor | Peck, Kyong Ran | - |
dc.contributor.nonIdAuthor | Song, Joon Young | - |
dc.contributor.nonIdAuthor | Lee, Jeong-Hoon | - |
dc.description.isOpenAccess | N | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | COVID-19 vaccines | - |
dc.subject.keywordAuthor | Chronic hepatitis B | - |
dc.subject.keywordAuthor | HBsAg | - |
dc.subject.keywordAuthor | NK cells | - |
dc.subject.keywordAuthor | NKG2A | - |
dc.subject.keywordPlus | NATURAL-KILLER-CELLS | - |
dc.subject.keywordPlus | IMMUNE-RESPONSES | - |
dc.subject.keywordPlus | INNATE | - |
dc.subject.keywordPlus | RECONSTITUTION | - |
dc.subject.keywordPlus | INFECTION | - |
dc.subject.keywordPlus | DISEASE | - |
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