Systematic analysis of homologous tandem repeat family in the human genome

Abstract

The vast majority of the human genome consists of repetitive elements that form many complex but highly-ordered patterns. In particular, tandem repeats, whose repeat units are placed adjacent to each other, form highly structured patterns in the human genome when homologous tandem repeats are close together. Herein, the structure of the homologous tandem repeat family (HTRF) is assessed using systematic analysis. In the proposed system for analyzing HTRF, the original tandem repeat units are derived using the characteristics of homology of HTRF, and represented in a diagram in order to show the structure of HTRF easily. The analysis results of the four HTRFs in the human genome are shown here and the proposed algorithm may be seen to be very efficient for analyzing HTRF via the comparison of three conventional algorithms.