DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lim, Danim | ko |
dc.contributor.author | Lee, Wonchul | ko |
dc.contributor.author | Hong, Jungwoo | ko |
dc.contributor.author | Gong, Jintaek | ko |
dc.contributor.author | Choi, Jonghoon | ko |
dc.contributor.author | Kim, Jaewook | ko |
dc.contributor.author | Lim, Seolhee | ko |
dc.contributor.author | Yoo, Sung Hyun | ko |
dc.contributor.author | Lee, Yunho | ko |
dc.contributor.author | Lee, Hee-Seung | ko |
dc.date.accessioned | 2023-10-17T06:03:47Z | - |
dc.date.available | 2023-10-17T06:03:47Z | - |
dc.date.created | 2023-07-12 | - |
dc.date.created | 2023-07-12 | - |
dc.date.created | 2023-07-12 | - |
dc.date.created | 2023-07-12 | - |
dc.date.issued | 2023-06 | - |
dc.identifier.citation | ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, v.62, no.39 | - |
dc.identifier.issn | 1433-7851 | - |
dc.identifier.uri | http://hdl.handle.net/10203/313447 | - |
dc.description.abstract | We introduce a novel cyclic & beta;-amino acid, trans-(3S,4R)-4-aminotetrahydrothiophene-3-carboxylic acid (ATTC), as a versatile building block for designing peptide foldamers with controlled secondary structures. We synthesized and characterized a series of & beta;-peptide hexamers containing ATTC using various techniques, including X-ray crystallography, circular dichroism, and NMR spectroscopy. Our findings reveal that ATTC-containing foldamers can adopt 12-helical conformations similar to their isosteres and offer the possibility of fine-tuning their properties via post-synthetic modifications. In particular, chemoselective conjugation strategies demonstrate that ATTC provides unique post-synthetic modification opportunities, which expand their potential applications across diverse research areas. Collectively, our study highlights the versatility and utility of ATTC as an alternative to previously reported cyclic & beta;-amino acid building blocks in both structural and functional aspects, paving the way for future research in the realm of peptide foldamers and beyond. | - |
dc.language | English | - |
dc.publisher | WILEY-V C H VERLAG GMBH | - |
dc.title | Versatile Post-synthetic Modifications of Helical β-Peptide Foldamers Derived from a Thioether-Containing Cyclic β-Amino Acid | - |
dc.type | Article | - |
dc.identifier.wosid | 001030344500001 | - |
dc.identifier.scopusid | 2-s2.0-85164467798 | - |
dc.type.rims | ART | - |
dc.citation.volume | 62 | - |
dc.citation.issue | 39 | - |
dc.citation.publicationname | ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | - |
dc.identifier.doi | 10.1002/anie.202305196 | - |
dc.contributor.localauthor | Lee, Hee-Seung | - |
dc.contributor.nonIdAuthor | Choi, Jonghoon | - |
dc.contributor.nonIdAuthor | Kim, Jaewook | - |
dc.contributor.nonIdAuthor | Lee, Yunho | - |
dc.description.isOpenAccess | N | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | amino acids | - |
dc.subject.keywordAuthor | foldamers | - |
dc.subject.keywordAuthor | peptidomimetics | - |
dc.subject.keywordAuthor | post-synthetic modification | - |
dc.subject.keywordPlus | SECONDARY STRUCTURE | - |
dc.subject.keywordPlus | BETA-PEPTIDES | - |
dc.subject.keywordPlus | PROTEINS | - |
dc.subject.keywordPlus | DESIGN | - |
dc.subject.keywordPlus | CHEMISTRY | - |
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