DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lyu, Xiang | ko |
dc.contributor.author | Seo, Changhyeon | ko |
dc.contributor.author | Jung, Hoimin | ko |
dc.contributor.author | Faber, Teresa | ko |
dc.contributor.author | Kim, Dongwook | ko |
dc.contributor.author | Seo, Sangwon | ko |
dc.contributor.author | Chang, Sukbok | ko |
dc.date.accessioned | 2023-10-17T06:03:03Z | - |
dc.date.available | 2023-10-17T06:03:03Z | - |
dc.date.created | 2023-10-11 | - |
dc.date.created | 2023-10-11 | - |
dc.date.issued | 2023-09 | - |
dc.identifier.citation | NATURE CATALYSIS, v.6, no.9, pp.784 - 795 | - |
dc.identifier.issn | 2520-1158 | - |
dc.identifier.uri | http://hdl.handle.net/10203/313445 | - |
dc.description.abstract | Synthetic methods for constructing enantioenriched beta-lactams are highly valuable given their ubiquity in bioactive compounds, most notably in antibiotics such as penicillins and carbapenems. Intramolecular hydroamidation of beta,gamma-unsaturated amides would provide a convenient means to reach this alluring chemical space, yet it remains limited due to the regioselectivity issue arising from the difficulty associated with the formation of strained four-membered rings. Here we describe a NiH-catalysed strategy that addresses this challenge through the use of readily accessible alkenyl dioxazolone derivatives. The reaction transcends the conventional NiH operation mode via a transposed mechanism initiated by N-activation, thus allowing for proximal C-N bond formation with excellent regioselectivity, regardless of the electronic properties of substituents. This mechanistic platform is also highly effective for the enantioselective intramolecular hydroamidation of alkenes to enable a convenient access to enantioenriched beta-lactams. | - |
dc.language | English | - |
dc.publisher | NATURE PORTFOLIO | - |
dc.title | Intramolecular hydroamidation of alkenes enabling asymmetric synthesis of beta-lactams via transposed NiH catalysis | - |
dc.type | Article | - |
dc.identifier.wosid | 001059860900001 | - |
dc.identifier.scopusid | 2-s2.0-85168595648 | - |
dc.type.rims | ART | - |
dc.citation.volume | 6 | - |
dc.citation.issue | 9 | - |
dc.citation.beginningpage | 784 | - |
dc.citation.endingpage | 795 | - |
dc.citation.publicationname | NATURE CATALYSIS | - |
dc.identifier.doi | 10.1038/s41929-023-01014-2 | - |
dc.contributor.localauthor | Chang, Sukbok | - |
dc.contributor.nonIdAuthor | Lyu, Xiang | - |
dc.contributor.nonIdAuthor | Faber, Teresa | - |
dc.contributor.nonIdAuthor | Seo, Sangwon | - |
dc.description.isOpenAccess | N | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordPlus | UNACTIVATED ALKENES | - |
dc.subject.keywordPlus | HYDROAMINATION | - |
dc.subject.keywordPlus | ALKYNES | - |
dc.subject.keywordPlus | INTERMEDIATE | - |
dc.subject.keywordPlus | COMPLEX | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.