DC Field | Value | Language |
---|---|---|
dc.contributor.author | Crump, Nicholas T. | ko |
dc.contributor.author | Smith, Alastair L. | ko |
dc.contributor.author | Godfrey, Laura | ko |
dc.contributor.author | Dopico-Fernandez, Ana M. | ko |
dc.contributor.author | Denny, Nicholas | ko |
dc.contributor.author | Harman, Joe R. | ko |
dc.contributor.author | Hamley, Joseph C. | ko |
dc.contributor.author | Jackson, Nicole E. | ko |
dc.contributor.author | Chahrour, Catherine | ko |
dc.contributor.author | Riva, Simone | ko |
dc.contributor.author | Rice, Siobhan | ko |
dc.contributor.author | Kim, Jaehoon | ko |
dc.contributor.author | Basrur, Venkatesha | ko |
dc.contributor.author | Fermin, Damian | ko |
dc.contributor.author | Elenitoba-Johnson, Kojo | ko |
dc.contributor.author | Roeder, Robert G. | ko |
dc.contributor.author | Allis, C. David | ko |
dc.contributor.author | Roberts, Irene | ko |
dc.contributor.author | Roy, Anindita | ko |
dc.contributor.author | Geng, Huimin | ko |
dc.contributor.author | Davies, James O. J. | ko |
dc.contributor.author | Milne, Thomas A. | ko |
dc.date.accessioned | 2023-10-04T06:01:26Z | - |
dc.date.available | 2023-10-04T06:01:26Z | - |
dc.date.created | 2023-10-04 | - |
dc.date.created | 2023-10-04 | - |
dc.date.issued | 2023-08 | - |
dc.identifier.citation | NATURE COMMUNICATIONS, v.14, no.1 | - |
dc.identifier.issn | 2041-1723 | - |
dc.identifier.uri | http://hdl.handle.net/10203/312965 | - |
dc.description.abstract | Aberrant enhancer activation is a key mechanism driving oncogene expression in many cancers. While much is known about the regulation of larger chromosome domains in eukaryotes, the details of enhancer-promoter interactions remain poorly understood. Recent work suggests co-activators like BRD4 and Mediator have little impact on enhancer-promoter interactions. In leukemias controlled by the MLL-AF4 fusion protein, we use the ultra-high resolution technique Micro-Capture-C (MCC) to show that MLL-AF4 binding promotes broad, high-density regions of enhancer-promoter interactions at a subset of key targets. These enhancers are enriched for transcription elongation factors like PAF1C and FACT, and the loss of these factors abolishes enhancer-promoter contact. This work not only provides an additional model for how MLL-AF4 is able to drive high levels of transcription at key genes in leukemia but also suggests a more general model linking enhancer-promoter crosstalk and transcription elongation. | - |
dc.language | English | - |
dc.publisher | NATURE PORTFOLIO | - |
dc.title | MLL-AF4 cooperates with PAF1 and FACT to drive high-density enhancer interactions in leukemia | - |
dc.type | Article | - |
dc.identifier.wosid | 001054831600014 | - |
dc.identifier.scopusid | 2-s2.0-85168749819 | - |
dc.type.rims | ART | - |
dc.citation.volume | 14 | - |
dc.citation.issue | 1 | - |
dc.citation.publicationname | NATURE COMMUNICATIONS | - |
dc.identifier.doi | 10.1038/s41467-023-40981-9 | - |
dc.contributor.localauthor | Kim, Jaehoon | - |
dc.contributor.nonIdAuthor | Crump, Nicholas T. | - |
dc.contributor.nonIdAuthor | Smith, Alastair L. | - |
dc.contributor.nonIdAuthor | Godfrey, Laura | - |
dc.contributor.nonIdAuthor | Dopico-Fernandez, Ana M. | - |
dc.contributor.nonIdAuthor | Denny, Nicholas | - |
dc.contributor.nonIdAuthor | Harman, Joe R. | - |
dc.contributor.nonIdAuthor | Hamley, Joseph C. | - |
dc.contributor.nonIdAuthor | Jackson, Nicole E. | - |
dc.contributor.nonIdAuthor | Chahrour, Catherine | - |
dc.contributor.nonIdAuthor | Riva, Simone | - |
dc.contributor.nonIdAuthor | Rice, Siobhan | - |
dc.contributor.nonIdAuthor | Basrur, Venkatesha | - |
dc.contributor.nonIdAuthor | Fermin, Damian | - |
dc.contributor.nonIdAuthor | Elenitoba-Johnson, Kojo | - |
dc.contributor.nonIdAuthor | Roeder, Robert G. | - |
dc.contributor.nonIdAuthor | Allis, C. David | - |
dc.contributor.nonIdAuthor | Roberts, Irene | - |
dc.contributor.nonIdAuthor | Roy, Anindita | - |
dc.contributor.nonIdAuthor | Geng, Huimin | - |
dc.contributor.nonIdAuthor | Davies, James O. J. | - |
dc.contributor.nonIdAuthor | Milne, Thomas A. | - |
dc.description.isOpenAccess | N | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordPlus | ACUTE LYMPHOBLASTIC-LEUKEMIA | - |
dc.subject.keywordPlus | RNA-POLYMERASE-II | - |
dc.subject.keywordPlus | MLL-FUSION PROTEINS | - |
dc.subject.keywordPlus | TRANSCRIPTION ELONGATION | - |
dc.subject.keywordPlus | GENE-EXPRESSION | - |
dc.subject.keywordPlus | MUTATIONAL LANDSCAPE | - |
dc.subject.keywordPlus | STATISTICAL-MODEL | - |
dc.subject.keywordPlus | H3K79 METHYLATION | - |
dc.subject.keywordPlus | SUPER-ENHANCERS | - |
dc.subject.keywordPlus | HIV-1 TAT | - |
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