DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, Gwangrog | ko |
dc.contributor.author | Rabbi, Mahir | ko |
dc.contributor.author | Clark, Robert L. | ko |
dc.contributor.author | Marszalek, Piotr E. | ko |
dc.date.accessioned | 2023-09-12T01:02:13Z | - |
dc.date.available | 2023-09-12T01:02:13Z | - |
dc.date.created | 2023-09-12 | - |
dc.date.issued | 2007-05 | - |
dc.identifier.citation | SMALL, v.3, no.5, pp.809 - 813 | - |
dc.identifier.issn | 1613-6810 | - |
dc.identifier.uri | http://hdl.handle.net/10203/312453 | - |
dc.description.abstract | The nanomechanical fingerprints elasticity of UV-damage to DNA in a dose- and sequence-dependent manner, using Atomic Force Microscopy (AFM)-based single-molecule force spectroscopy, was analyzed. The force spectrograms results indicate a significant differences in the elasticity of UV-treated individual DNA molecules as compared to the untreated DNA. The UV treatment shortens the B-S DNA transition length below 70% of the original contour length measured for the untreated DNA. The elasticity of individual duplexes exposed to various doses of radiations of UV light shows that the shortening of the B-S transition is equivalent to that recorded on UV-irradiated DNA. The results also show that UV radiation affects the mechanics of DNA double helix at a single-molecule level in a dose-dependent manner and the irradiated synthetic DNA shows a damage saturation in a sequence-dependent manner. | - |
dc.language | English | - |
dc.publisher | WILEY-V C H VERLAG GMBH | - |
dc.title | Nanomechanical fingerprints of UV damage to DNA | - |
dc.type | Article | - |
dc.identifier.wosid | 000246557200013 | - |
dc.identifier.scopusid | 2-s2.0-34248550730 | - |
dc.type.rims | ART | - |
dc.citation.volume | 3 | - |
dc.citation.issue | 5 | - |
dc.citation.beginningpage | 809 | - |
dc.citation.endingpage | 813 | - |
dc.citation.publicationname | SMALL | - |
dc.identifier.doi | 10.1002/smll.200600592 | - |
dc.contributor.localauthor | Lee, Gwangrog | - |
dc.contributor.nonIdAuthor | Rabbi, Mahir | - |
dc.contributor.nonIdAuthor | Clark, Robert L. | - |
dc.contributor.nonIdAuthor | Marszalek, Piotr E. | - |
dc.description.isOpenAccess | N | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | atomic force microscopy | - |
dc.subject.keywordAuthor | DNA | - |
dc.subject.keywordAuthor | force spectroscopy | - |
dc.subject.keywordAuthor | single molecules | - |
dc.subject.keywordAuthor | UV damage | - |
dc.subject.keywordPlus | SINGLE-MOLECULE | - |
dc.subject.keywordPlus | ELASTICITY | - |
dc.subject.keywordPlus | LESIONS | - |
dc.subject.keywordPlus | SPECTROSCOPY | - |
dc.subject.keywordPlus | TRANSITIONS | - |
dc.subject.keywordPlus | SEQUENCE | - |
dc.subject.keywordPlus | TENSION | - |
dc.subject.keywordPlus | REPAIR | - |
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