DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Kyukwang | ko |
dc.contributor.author | Kim, Mooyoung | ko |
dc.contributor.author | Lee, Andrew J. | ko |
dc.contributor.author | Song, Sang-Hyun | ko |
dc.contributor.author | Kang, Jun-Kyu | ko |
dc.contributor.author | Eom, Junghyun | ko |
dc.contributor.author | Kim, Young-Joon | ko |
dc.contributor.author | Kang, Gyeong Hoon | ko |
dc.contributor.author | Bae, Jeong Mo | ko |
dc.contributor.author | Min, Sunwoo | ko |
dc.contributor.author | Kim, Yeonsoo | ko |
dc.contributor.author | Lim, Yoojoo | ko |
dc.contributor.author | Kim, Han Sang | ko |
dc.contributor.author | Kim, Tae -You | ko |
dc.contributor.author | Jung, Inkyung | ko |
dc.date.accessioned | 2023-08-22T06:01:43Z | - |
dc.date.available | 2023-08-22T06:01:43Z | - |
dc.date.created | 2023-08-22 | - |
dc.date.created | 2023-08-22 | - |
dc.date.created | 2023-08-22 | - |
dc.date.created | 2023-08-22 | - |
dc.date.issued | 2023-07 | - |
dc.identifier.citation | CELL REPORTS, v.42, no.7 | - |
dc.identifier.issn | 2211-1247 | - |
dc.identifier.uri | http://hdl.handle.net/10203/311698 | - |
dc.description.abstract | The regulatory effect of non-coding large-scale structural variations (SVs) on proto-oncogene activation re-mains unclear. This study investigated SV-mediated gene dysregulation by profiling 3D cancer genome maps from 40 patients with colorectal cancer (CRC). We developed a machine learning-based method for spatial characterization of the altered 3D cancer genome. This revealed a frequent establishment of "de novo chromatin contacts"that can span multiple topologically associating domains (TADs) in addition to the canonical TAD fusion/shuffle model. Using this information, we precisely identified super-enhancer (SE)-hijacking and its clonal characteristics. Clonal SE-hijacking genes, such as TOP2B, are recurrently associated with cell-cycle/DNA-processing functions, which can potentially be used as CRC prognostic markers. Oncogene activa-tion and increased drug resistance due to SE-hijacking were validated by reconstructing the patient's SV using CRISPR-Cas9. Collectively, the spatial and clonality-resolved analysis of the 3D cancer genome re-veals regulatory principles of large-scale SVs in oncogene activation and their clinical implications. | - |
dc.language | English | - |
dc.publisher | CELL PRESS | - |
dc.title | Spatial and clonality-resolved 3D cancer genome alterations reveal enhancer-hijacking as a potential prognostic marker for colorectal cancer | - |
dc.type | Article | - |
dc.identifier.wosid | 001043248900001 | - |
dc.identifier.scopusid | 2-s2.0-85165274168 | - |
dc.type.rims | ART | - |
dc.citation.volume | 42 | - |
dc.citation.issue | 7 | - |
dc.citation.publicationname | CELL REPORTS | - |
dc.identifier.doi | 10.1016/j.celrep.2023.112778 | - |
dc.contributor.localauthor | Jung, Inkyung | - |
dc.contributor.nonIdAuthor | Song, Sang-Hyun | - |
dc.contributor.nonIdAuthor | Kang, Jun-Kyu | - |
dc.contributor.nonIdAuthor | Kim, Young-Joon | - |
dc.contributor.nonIdAuthor | Kang, Gyeong Hoon | - |
dc.contributor.nonIdAuthor | Bae, Jeong Mo | - |
dc.contributor.nonIdAuthor | Kim, Yeonsoo | - |
dc.contributor.nonIdAuthor | Lim, Yoojoo | - |
dc.contributor.nonIdAuthor | Kim, Han Sang | - |
dc.contributor.nonIdAuthor | Kim, Tae -You | - |
dc.description.isOpenAccess | N | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | 3D cancer genome | - |
dc.subject.keywordAuthor | clonality | - |
dc.subject.keywordAuthor | colorectal cancer | - |
dc.subject.keywordAuthor | CP: Cancer | - |
dc.subject.keywordAuthor | CP: Genomics | - |
dc.subject.keywordAuthor | enhancer-hijacking | - |
dc.subject.keywordAuthor | in situ Hi-C | - |
dc.subject.keywordAuthor | prognostic marker | - |
dc.subject.keywordAuthor | structural variations | - |
dc.subject.keywordPlus | COPY NUMBER | - |
dc.subject.keywordPlus | CHROMATIN | - |
dc.subject.keywordPlus | DOMAINS | - |
dc.subject.keywordPlus | ORGANIZATION | - |
dc.subject.keywordPlus | DISRUPTION | - |
dc.subject.keywordPlus | TRANSCRIPT | - |
dc.subject.keywordPlus | PRINCIPLES | - |
dc.subject.keywordPlus | HISAT | - |
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