DC Field | Value | Language |
---|---|---|
dc.contributor.author | Baker, Matthew | ko |
dc.contributor.author | Kang, Seungwoo | ko |
dc.contributor.author | Hong, Sa-Ik | ko |
dc.contributor.author | Song, Minryung | ko |
dc.contributor.author | Yang, Minsu Abel | ko |
dc.contributor.author | Peyton, Lee | ko |
dc.contributor.author | Essa, Hesham | ko |
dc.contributor.author | Lee, Sang Wan | ko |
dc.contributor.author | Choi, Doo-Sup | ko |
dc.date.accessioned | 2023-08-22T06:01:13Z | - |
dc.date.available | 2023-08-22T06:01:13Z | - |
dc.date.created | 2023-08-22 | - |
dc.date.created | 2023-08-22 | - |
dc.date.issued | 2023-07 | - |
dc.identifier.citation | NATURE COMMUNICATIONS, v.14, no.1 | - |
dc.identifier.issn | 2041-1723 | - |
dc.identifier.uri | http://hdl.handle.net/10203/311696 | - |
dc.description.abstract | The external globus pallidus (GPe) coordinates action-selection through GABAergic projections throughout the basal ganglia. GPe arkypallidal (arky) neurons project exclusively to the dorsal striatum, which regulates goal-directed and habitual seeking. However, the role of GPe arky neurons in reward-seeking remains unknown. Here, we identified that a majority of arky neurons target the dorsolateral striatum (DLS). Using fiber photometry, we found that arky activities were higher during random interval (RI; habit) compared to random ratio (RR; goal) operant conditioning. Support vector machine analysis demonstrated that arky neuron activities have sufficient information to distinguish between RR and RI behavior. Genetic ablation of this arky(GPe & RARR;DLS) circuit facilitated a shift from goal-directed to habitual behavior. Conversely, chemogenetic activation globally reduced seeking behaviors, which was blocked by systemic D1R agonism. Our findings reveal a role of this arky(GPe & RARR;DLS) circuit in constraining habitual seeking in male mice, which is relevant to addictive behaviors and other compulsive disorders. The external part of the globus pallidus is involved in action-selection. Here, the authors investigate the function of an arkypallidal neuronal circuit to the dorsolateral striatum in goal-directed and habitual-seeking behaviors in male mice. | - |
dc.language | English | - |
dc.publisher | NATURE PORTFOLIO | - |
dc.title | External globus pallidus input to the dorsal striatum regulates habitual seeking behavior in male mice | - |
dc.type | Article | - |
dc.identifier.wosid | 001029450400017 | - |
dc.identifier.scopusid | 2-s2.0-85164542668 | - |
dc.type.rims | ART | - |
dc.citation.volume | 14 | - |
dc.citation.issue | 1 | - |
dc.citation.publicationname | NATURE COMMUNICATIONS | - |
dc.identifier.doi | 10.1038/s41467-023-39545-8 | - |
dc.contributor.localauthor | Lee, Sang Wan | - |
dc.contributor.nonIdAuthor | Baker, Matthew | - |
dc.contributor.nonIdAuthor | Kang, Seungwoo | - |
dc.contributor.nonIdAuthor | Hong, Sa-Ik | - |
dc.contributor.nonIdAuthor | Yang, Minsu Abel | - |
dc.contributor.nonIdAuthor | Peyton, Lee | - |
dc.contributor.nonIdAuthor | Essa, Hesham | - |
dc.contributor.nonIdAuthor | Choi, Doo-Sup | - |
dc.description.isOpenAccess | N | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordPlus | BASAL GANGLIA | - |
dc.subject.keywordPlus | DOPAMINE-RECEPTORS | - |
dc.subject.keywordPlus | DRUG-ADDICTION | - |
dc.subject.keywordPlus | IN-VIVO | - |
dc.subject.keywordPlus | NEURONS | - |
dc.subject.keywordPlus | CIRCUIT | - |
dc.subject.keywordPlus | STIMULATION | - |
dc.subject.keywordPlus | ACQUISITION | - |
dc.subject.keywordPlus | DYSFUNCTION | - |
dc.subject.keywordPlus | INDUCTION | - |
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