DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kang, Shinwoo | ko |
dc.contributor.author | Hong, Sa-Ik | ko |
dc.contributor.author | Kang, Seungwoo | ko |
dc.contributor.author | Song, Minryung | ko |
dc.contributor.author | Yang, Minsu Abel | ko |
dc.contributor.author | Essa, Hesham | ko |
dc.contributor.author | Baker, Matthew | ko |
dc.contributor.author | Lee, Jeyeon | ko |
dc.contributor.author | Bruce, Robert A. | ko |
dc.contributor.author | Lee, Sang Wan | ko |
dc.contributor.author | Choi, Doo-Sup | ko |
dc.date.accessioned | 2023-08-08T01:00:11Z | - |
dc.date.available | 2023-08-08T01:00:11Z | - |
dc.date.created | 2023-08-07 | - |
dc.date.created | 2023-08-07 | - |
dc.date.issued | 2023-06 | - |
dc.identifier.citation | SCIENCE ADVANCES, v.9, no.24 | - |
dc.identifier.issn | 2375-2548 | - |
dc.identifier.uri | http://hdl.handle.net/10203/311215 | - |
dc.description.abstract | An imbalance in goal-directed and habitual behavioral control is a hallmark of decision-making-related disorders, including addiction. Although external globus pallidus (GPe) is critical for action selection, which harbors enriched astrocytes, the role of GPe astrocytes involved in action-selection strategies remained unknown. Using in vivo calcium signaling with fiber photometry, we found substantially attenuated GPe astrocytic activity during habitual learning compared to goal-directed learning. The support vector machine analysis predicted the behavioral outcomes. Chemogenetic activation of the astrocytes or inhibition of GPe pan-neuronal activities facilitates the transition from habit to goal-directed reward-seeking behavior. Next, we found increased astrocyte-specific GABA (& gamma;-aminobutyric acid) transporter type 3 (GAT3) messenger RNA expression during habit learning. Notably, the pharmacological inhibition of GAT3 occluded astrocyte activation-induced transition from habitual to goal-directed behavior. On the other hand, attentional stimuli shifted the habit to goal-directed behaviors. Our findings suggest that the GPe astrocytes regulate the action selection strategy and behavioral flexibility. | - |
dc.language | English | - |
dc.publisher | AMER ASSOC ADVANCEMENT SCIENCE | - |
dc.title | Astrocyte activities in the external globus pallidus regulate action-selection strategies in reward-seeking behaviors | - |
dc.type | Article | - |
dc.identifier.wosid | 001012158900022 | - |
dc.identifier.scopusid | 2-s2.0-85163904678 | - |
dc.type.rims | ART | - |
dc.citation.volume | 9 | - |
dc.citation.issue | 24 | - |
dc.citation.publicationname | SCIENCE ADVANCES | - |
dc.identifier.doi | 10.1126/sciadv.adh9239 | - |
dc.contributor.localauthor | Lee, Sang Wan | - |
dc.contributor.nonIdAuthor | Kang, Shinwoo | - |
dc.contributor.nonIdAuthor | Hong, Sa-Ik | - |
dc.contributor.nonIdAuthor | Kang, Seungwoo | - |
dc.contributor.nonIdAuthor | Yang, Minsu Abel | - |
dc.contributor.nonIdAuthor | Essa, Hesham | - |
dc.contributor.nonIdAuthor | Baker, Matthew | - |
dc.contributor.nonIdAuthor | Lee, Jeyeon | - |
dc.contributor.nonIdAuthor | Bruce, Robert A. | - |
dc.contributor.nonIdAuthor | Choi, Doo-Sup | - |
dc.description.isOpenAccess | N | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordPlus | BASAL GANGLIA | - |
dc.subject.keywordPlus | SUSTAINED ATTENTION | - |
dc.subject.keywordPlus | DRUG-ADDICTION | - |
dc.subject.keywordPlus | NEURAL SYSTEMS | - |
dc.subject.keywordPlus | NEURONS | - |
dc.subject.keywordPlus | HABIT | - |
dc.subject.keywordPlus | ROLES | - |
dc.subject.keywordPlus | DYSFUNCTION | - |
dc.subject.keywordPlus | HYPERACTIVITY | - |
dc.subject.keywordPlus | NEUROSCIENCE | - |
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