DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Hee-Hoon | ko |
dc.contributor.author | Shim, Young-Ri | ko |
dc.contributor.author | Kim, Ha Neul | ko |
dc.contributor.author | Yang, Keungmo | ko |
dc.contributor.author | Ryu, Tom | ko |
dc.contributor.author | Kim, Kyurae | ko |
dc.contributor.author | Choi, Sung Eun | ko |
dc.contributor.author | Kim, Min Jeong | ko |
dc.contributor.author | Woo, Chaerin | ko |
dc.contributor.author | Chung, Katherine Po Sin | ko |
dc.contributor.author | Hong, Song Hwa | ko |
dc.contributor.author | Shin, Hyemi | ko |
dc.contributor.author | Suh, Jae Myoung | ko |
dc.contributor.author | Jung, Youngae | ko |
dc.contributor.author | Hwang, Geum-Sook | ko |
dc.contributor.author | Kim, Won | ko |
dc.contributor.author | Kim, Seok-Hwan | ko |
dc.contributor.author | Eun, Hyuk Soo | ko |
dc.contributor.author | Seong, Je Kyung | ko |
dc.contributor.author | Jeong, Won-Il | ko |
dc.date.accessioned | 2023-08-01T02:02:03Z | - |
dc.date.available | 2023-08-01T02:02:03Z | - |
dc.date.created | 2023-07-31 | - |
dc.date.created | 2023-07-31 | - |
dc.date.created | 2023-07-31 | - |
dc.date.issued | 2023-06 | - |
dc.identifier.citation | CELL REPORTS, v.42, no.6 | - |
dc.identifier.issn | 2211-1247 | - |
dc.identifier.uri | http://hdl.handle.net/10203/310980 | - |
dc.description.abstract | Obesity-mediated hypoxic stress underlies inflammation, including interferon (IFN)-y production by natural killer (NK) cells in white adipose tissue. However, the effects of obesity on NK cell IFN-y production remain obscure. Here, we show that hypoxia promotes xCT-mediated glutamate excretion and C-X-C motif chemokine ligand 12 (CXCL12) expression in white adipocytes, resulting in CXCR4+ NK cell recruitment. Interestingly, this spatial proximity between adipocytes and NK cells induces IFN-y production in NK cells by stimulating metabotropic glutamate receptor 5 (mGluR5). IFN-y then triggers inflammatory activation of macrophages and augments xCT and CXCL12 expression in adipocytes, forming a bidirectional pathway. Genetic or pharmacological inhibition of xCT, mGluR5, or IFN-y receptor in adipocytes or NK cells alleviates obesity-related metabolic disorders in mice. Consistently, patients with obesity showed elevated levels of glutamate/mGluR5 and CXCL12/CXCR4 axes, suggesting that a bidirectional pathway between adipocytes and NK cells could be a viable therapeutic target in obesity-related metabolic disorders. | - |
dc.language | English | - |
dc.publisher | CELL PRESS | - |
dc.title | xCT-mediated glutamate excretion in white adipocytes stimulates interferon-y production by natural killer cells in obesity | - |
dc.type | Article | - |
dc.identifier.wosid | 001026561500001 | - |
dc.identifier.scopusid | 2-s2.0-85162062059 | - |
dc.type.rims | ART | - |
dc.citation.volume | 42 | - |
dc.citation.issue | 6 | - |
dc.citation.publicationname | CELL REPORTS | - |
dc.identifier.doi | 10.1016/j.celrep.2023.112636 | - |
dc.contributor.localauthor | Suh, Jae Myoung | - |
dc.contributor.localauthor | Jeong, Won-Il | - |
dc.contributor.nonIdAuthor | Kim, Ha Neul | - |
dc.contributor.nonIdAuthor | Jung, Youngae | - |
dc.contributor.nonIdAuthor | Hwang, Geum-Sook | - |
dc.contributor.nonIdAuthor | Kim, Won | - |
dc.contributor.nonIdAuthor | Kim, Seok-Hwan | - |
dc.contributor.nonIdAuthor | Seong, Je Kyung | - |
dc.description.isOpenAccess | N | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordPlus | ADIPOSE-TISSUE | - |
dc.subject.keywordPlus | INSULIN-RESISTANCE | - |
dc.subject.keywordPlus | INFLAMMATION | - |
dc.subject.keywordPlus | MACROPHAGES | - |
dc.subject.keywordPlus | RECEPTORS | - |
dc.subject.keywordPlus | HYPOXIA | - |
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