Graphene oxide coated fabric layers for the efficient isolation of circulating tumor cells

Abstract

We present the fabric sheet layers, functionalized with graphene oxide (GO) for the sensitive isolation of circulating tumor cells (CTCs). Compared to the previous microfluidic-based CTC detection devices, which require complicated and long fabrication processes, the fabric sheet layers are simply fabricated by conventional textile manufacturing; thus the device is mass producible at extremely low-cost. Furthermore, since the present layers are composed of polyester yarns, GO can be directly modified on the surface after only a half hour of surface modification preprocess with protein, bovine serum albumin (BSA); thus, it has boundless potential for bioapplications. Here we demonstrated the fabric sheet layers and their simple modification methods to achieve high sensitive CTC isolation.