DC Field | Value | Language |
---|---|---|
dc.contributor.author | Park, Jimin | ko |
dc.contributor.author | Zeng, Joy S. | ko |
dc.contributor.author | Sahasrabudhe, Atharva | ko |
dc.contributor.author | Jin, Kyoungsuk | ko |
dc.contributor.author | Fink, Yoel | ko |
dc.contributor.author | Manthiram, Karthish | ko |
dc.contributor.author | Anikeeva, Polina | ko |
dc.date.accessioned | 2023-07-10T07:00:37Z | - |
dc.date.available | 2023-07-10T07:00:37Z | - |
dc.date.created | 2023-07-10 | - |
dc.date.created | 2023-07-10 | - |
dc.date.issued | 2021-09 | - |
dc.identifier.citation | ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, v.60, no.37, pp.20325 - 20330 | - |
dc.identifier.issn | 1433-7851 | - |
dc.identifier.uri | http://hdl.handle.net/10203/310401 | - |
dc.description.abstract | Despite the critical role played by carbon monoxide (CO) in physiological and pathological signaling events, current approaches to deliver this messenger molecule are often accompanied by off-target effects and offer limited control over release kinetics. To address these challenges, we develop an electrochemical approach that affords on-demand release of CO through reduction of carbon dioxide (CO2) dissolved in the extracellular space. Electrocatalytic generation of CO by cobalt phthalocyanine molecular catalysts modulates signaling pathways mediated by a CO receptor soluble guanylyl cyclase. Furthermore, by tuning the applied voltage during electrocatalysis, we explore the effect of the CO release kinetics on CO-dependent neuronal signaling. Finally, we integrate components of our electrochemical platform into microscale fibers to produce CO in a spatially-restricted manner and to activate signaling cascades in the targeted cells. By offering on-demand local synthesis of CO, our approach may facilitate the studies of physiological processes affected by this gaseous molecular messenger. | - |
dc.language | English | - |
dc.publisher | WILEY-V C H VERLAG GMBH | - |
dc.title | Electrochemical Modulation of Carbon Monoxide-Mediated Cell Signaling | - |
dc.type | Article | - |
dc.identifier.wosid | 000683708500001 | - |
dc.identifier.scopusid | 2-s2.0-85112101378 | - |
dc.type.rims | ART | - |
dc.citation.volume | 60 | - |
dc.citation.issue | 37 | - |
dc.citation.beginningpage | 20325 | - |
dc.citation.endingpage | 20330 | - |
dc.citation.publicationname | ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | - |
dc.identifier.doi | 10.1002/anie.202103228 | - |
dc.contributor.localauthor | Park, Jimin | - |
dc.contributor.nonIdAuthor | Zeng, Joy S. | - |
dc.contributor.nonIdAuthor | Sahasrabudhe, Atharva | - |
dc.contributor.nonIdAuthor | Jin, Kyoungsuk | - |
dc.contributor.nonIdAuthor | Fink, Yoel | - |
dc.contributor.nonIdAuthor | Manthiram, Karthish | - |
dc.contributor.nonIdAuthor | Anikeeva, Polina | - |
dc.description.isOpenAccess | N | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | carbon monoxide | - |
dc.subject.keywordAuthor | cell signaling | - |
dc.subject.keywordAuthor | electrochemistry | - |
dc.subject.keywordAuthor | fiber drawing | - |
dc.subject.keywordAuthor | receptors | - |
dc.subject.keywordPlus | NITRIC-OXIDE | - |
dc.subject.keywordPlus | CA2+ CHANNELS | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | MOLECULES | - |
dc.subject.keywordPlus | CYCLASE | - |
dc.subject.keywordPlus | BICARBONATE | - |
dc.subject.keywordPlus | CO | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.