DC Field | Value | Language |
---|---|---|
dc.contributor.advisor | Choi, Chulhee | - |
dc.contributor.advisor | 최철희 | - |
dc.contributor.author | Baek, Gyu Hyeon | - |
dc.date.accessioned | 2023-06-23T19:30:56Z | - |
dc.date.available | 2023-06-23T19:30:56Z | - |
dc.date.issued | 2019 | - |
dc.identifier.uri | http://library.kaist.ac.kr/search/detail/view.do?bibCtrlNo=1007028&flag=dissertation | en_US |
dc.identifier.uri | http://hdl.handle.net/10203/308748 | - |
dc.description | 학위논문(석사) - 한국과학기술원 : 바이오및뇌공학과, 2019.2,[iv, 44 p. :] | - |
dc.description.abstract | Triple negative breast cancer affects tens of thousands of women all around the world. Out of many TNBC targets, STAT3 is proven to have oncogenic potentials in the TNBC and several STAT3 inhibitors have been developed. However, because of several disadvantages, low stability, membrane permeability, and specificity, many STAT3 inhibitors failed to be used at the clinics. In this research, I propose a new specific regimen for TNBC. This new regimen is a combination of phosphotyrosine-STAT3 specific antibody and a delivery vehicle called exosomes. By compensating low stability and membrane permeability with exosomes and low specificity with antibody, combination of antibody and exosomes will show synergistic therapeutic potential. In addition, from this study, I was first to confirmed the therapeutic potential of specifically targeting phosphotyrosine-STAT3 in TNBC compared to existing studies that indirectly inhibited phosphotyrosine-STAT3 using small chemicals, protein knockdown and dominant negative form expression. | - |
dc.language | eng | - |
dc.publisher | 한국과학기술원 | - |
dc.subject | Triple negative breast cancer▼aSTAT3▼apYSTAT3 specific antibody▼aSTAT3 inhibitors▼aExosomes▼aEXPLOR▼aTargeted therapy | - |
dc.subject | 삼중음성유방암▼aSTAT3▼aPhosphotyrosine-STAT3 항체▼aSTAT3 억제제▼a엑소좀▼a표적치료제▼aEXPLOR | - |
dc.title | Anti-tumor effects of phospho-STAT3 antibody loading exosomes on triple negative breast cancer | - |
dc.title.alternative | 종양 억제 pYSTAT3-항체 탑재 엑소좀을 이용한 삼중음성유방암 억제에 관한 연구 | - |
dc.type | Thesis(Master) | - |
dc.identifier.CNRN | 325007 | - |
dc.description.department | 한국과학기술원 :바이오및뇌공학과, | - |
dc.contributor.alternativeauthor | 백규현 | - |
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