DC Field | Value | Language |
---|---|---|
dc.contributor.advisor | Park, Hyun Gyu | - |
dc.contributor.advisor | 박현규 | - |
dc.contributor.author | Kim, Hyo Yong | - |
dc.date.accessioned | 2023-06-22T19:33:31Z | - |
dc.date.available | 2023-06-22T19:33:31Z | - |
dc.date.issued | 2021 | - |
dc.identifier.uri | http://library.kaist.ac.kr/search/detail/view.do?bibCtrlNo=1021085&flag=dissertation | en_US |
dc.identifier.uri | http://hdl.handle.net/10203/308504 | - |
dc.description | 학위논문(박사) - 한국과학기술원 : 생명화학공학과, 2021.2,[xvii, 165 p. :] | - |
dc.description.abstract | Personal glucose meter (PGM) is one of the most widely commercialized portable device that enables the self-diagnosis of diabetes by measuring blood glucose level. By taking advantages of its meritorious features including portability, cost-effectiveness, and ease of operation, there have been extensive research to develop novel biosensors that utilize PGM for the detection of various non-glucose biomolecules such as small molecule, protein, and nucleic acid during the last decade. Notably, the employment of PGM as a detection device paved a new way for the development of point-of-care (POC) system that can be simply applied in the facility-limited environments. Despite these highly promising characteristics of PGM, however, the previous PGM-utilized biomolecular detection strategies have still showed several disadvantages such as the preparation of enzyme-labeled DNA probe and the requirement of magnetic separation step, which makes the entire detection procedure time-consuming and labor-intensive. To overcome these limitations, we have developed novel PGM-utilized label-free and washing-free methods for the simple on-site biomolecular detection by employing kinase-catalyzed cascade enzymatic reaction (KCER), glucose oxidase-mimicking activity of cerium oxide nanoparticle (CeO2 NP), and target-induced peroxidase catalysis, overcoming the disadvantages of the previously reported technologies. | - |
dc.language | eng | - |
dc.publisher | 한국과학기술원 | - |
dc.subject | Personal glucose meter▼aPoint-of-care testing▼aKinase-catalyzed cascade enzymatic reaction▼aCerium oxide nanoparticle▼aPeroxidase | - |
dc.subject | 자가혈당측정기▼a현장진단▼a인산화효소 연쇄 반응▼a산화 세륨 나노 입자▼a과산화효소 | - |
dc.title | Personal glucose meter-utilized methods for on-site biomolecular detection | - |
dc.title.alternative | 자가혈당측정기를 활용한 생체 물질 현장 검출 기술 개발 | - |
dc.type | Thesis(Ph.D) | - |
dc.identifier.CNRN | 325007 | - |
dc.description.department | 한국과학기술원 :생명화학공학과, | - |
dc.contributor.alternativeauthor | 김효용 | - |
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