DC Field | Value | Language |
---|---|---|
dc.contributor.advisor | Chung, Won-Suk | - |
dc.contributor.advisor | 정원석 | - |
dc.contributor.author | Lee, Joon-Hyuk | - |
dc.date.accessioned | 2023-06-22T19:33:17Z | - |
dc.date.available | 2023-06-22T19:33:17Z | - |
dc.date.issued | 2022 | - |
dc.identifier.uri | http://library.kaist.ac.kr/search/detail/view.do?bibCtrlNo=1007813&flag=dissertation | en_US |
dc.identifier.uri | http://hdl.handle.net/10203/308461 | - |
dc.description | 학위논문(박사) - 한국과학기술원 : 생명과학과, 2022.8,[vi, 134 p. :] | - |
dc.description.abstract | In the adult brain, synapses undergo constant formation and elimination. However, the exact function and DBS 이준혁. 별아교세포의 성체 시냅스 포식에 의한 구조적 가소성 연구. 생명과학과. 2022년. 134+vi 쪽. 지도교수: 정원석. (영문 논문) Joon-Hyuk Lee. Mechanisms of Structural Plasticity of adult synapses by Astrocytic Phagocytosis. 2022. 134+vi pages. Advisor: Won-Suk Chung. (Text in English) ii regulatory process of synapse elimination in the adult brain are largely unknown. Here, we reveal a significant role of astrocytic phagocytosis in the diverse region of adult brain. By utilizing mCherry-eGFP phagocytosis reporters, we find that synapses are eliminated by astrocytic phagocytosis in the adult hippocampal CA1, primary visual cortex and olfactory bulb. Surprisingly, our data show that astrocyte-mediated synapse elimination is critical for maintaining synaptic homeostasis as well as synapse remodeling in response to sensory alteration and neurogenesis. Furthermore, knocking-out the phagocytic receptor Megf10 in adult astrocytes reduces their ability to eliminate excitatory synapses, and as a result, induces the deficits in the synapse remodeling. Taken together, our data provide strong evidence that astrocytes eliminate the unwanted excitatory synaptic connections in the adult brain through MEGF10-dependent phagocytosis, and that this astrocytic function is critical for structural synaptic plasticity. | - |
dc.language | eng | - |
dc.publisher | 한국과학기술원 | - |
dc.subject | Astrocyte▼aSyanptic plasticity▼aPhagocytosis▼aMEGF10 | - |
dc.subject | 별아교세포▼a시냅스 가소성▼a포식작용▼aMEGF10 | - |
dc.title | Mechanisms of structural plasticity of adult synapses by astrocytic phagocytosis | - |
dc.title.alternative | 별아교세포의 성체 시냅스 포식에 의한 구조적 가소성 연구 | - |
dc.type | Thesis(Ph.D) | - |
dc.identifier.CNRN | 325007 | - |
dc.description.department | 한국과학기술원 :생명과학과, | - |
dc.contributor.alternativeauthor | 이준혁 | - |
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