DC Field | Value | Language |
---|---|---|
dc.contributor.advisor | Lee, Daeyoup | - |
dc.contributor.advisor | 이대엽 | - |
dc.contributor.author | Chun, Yujin | - |
dc.date.accessioned | 2023-06-22T19:33:13Z | - |
dc.date.available | 2023-06-22T19:33:13Z | - |
dc.date.issued | 2022 | - |
dc.identifier.uri | http://library.kaist.ac.kr/search/detail/view.do?bibCtrlNo=1021077&flag=dissertation | en_US |
dc.identifier.uri | http://hdl.handle.net/10203/308447 | - |
dc.description | 학위논문(박사) - 한국과학기술원 : 생명과학과, 2022.2,[v, 112 p. :] | - |
dc.description.abstract | A highly conserved nuclear exosome complex, which contains 3’-5’ exonuclease activity, plays a critical role in processing various types of RNAs and degrading unstable and aberrantly transcribed RNAs. Here, we discover the role of the nuclear exosome in regulating the positioning of cohesin at highly transcribed convergent genes. We use in situ Hi-C to show that the nuclear exosome regulates intra-chromosomal interactions and the formation of interacting domain boundaries through cohesin regulation. However, the exosome-coupled transcription termination does not affect the chromatin 3D organization. Instead, we found a close correlation between the cohesin positioning and the defective transcription elongation observed in the exosome-depleted cells. Altogether, these results suggest the novel functions of nuclear exosome in proper positioning of cohesin, the maintenance of chromatin 3D organization, and gene expression. | - |
dc.language | eng | - |
dc.publisher | 한국과학기술원 | - |
dc.subject | Nuclear Exosome▼aRrp6▼aCohesin▼ain-situ Hi-C▼afission yeast | - |
dc.subject | 핵 내 엑소좀▼a코히신▼a염색질 삼차원 구조▼a도메인 경계▼a분열효모 | - |
dc.title | Mechanistic study of chromatin 3D organization by the nuclear exosome | - |
dc.title.alternative | 핵 내 엑소좀에 의한 염색질 삼차원 구조 조절에 관한 연구 | - |
dc.type | Thesis(Ph.D) | - |
dc.identifier.CNRN | 325007 | - |
dc.description.department | 한국과학기술원 :생명과학과, | - |
dc.contributor.alternativeauthor | 천유진 | - |
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