DC Field | Value | Language |
---|---|---|
dc.contributor.advisor | Choi, Myung Chul | - |
dc.contributor.advisor | 최명철 | - |
dc.contributor.author | Lee, Juncheol | - |
dc.date.accessioned | 2023-06-21T19:34:25Z | - |
dc.date.available | 2023-06-21T19:34:25Z | - |
dc.date.issued | 2022 | - |
dc.identifier.uri | http://library.kaist.ac.kr/search/detail/view.do?bibCtrlNo=996465&flag=dissertation | en_US |
dc.identifier.uri | http://hdl.handle.net/10203/308053 | - |
dc.description | 학위논문(박사) - 한국과학기술원 : 바이오및뇌공학과, 2022.2,[v, 76 p. :] | - |
dc.description.abstract | Tubulins are protein building blocks that are naturally preprogrammed to assemble into cytoskeletal microtubules (MTs). In this thesis, cationic polymers are used as a molecular switch, which triggers two-dimensional (2D) conformational changes of tubulins, to control tubulin-based nano-architectures. Synchrotron small-angle X-ray scattering (SAXS) and transmission electron microscopy (TEM) reveal ‘tubulin double helices’ and tubulin double helix-based architectures in nanoscale. The new architectures are controlled by the size and concentration of cationic polymers, which suggests a mechanism of the molecular switch. Finally, tubulin-based nanotubes were developed for the application as anticancer drug delivery carriers. | - |
dc.language | eng | - |
dc.publisher | 한국과학기술원 | - |
dc.title | Tubulin architectures by cationic polymer molecular switch | - |
dc.title.alternative | 양이온 중합체 분자스위치에 의한 튜불린 아키텍처에 대한 연구 | - |
dc.type | Thesis(Ph.D) | - |
dc.identifier.CNRN | 325007 | - |
dc.description.department | 한국과학기술원 :바이오및뇌공학과, | - |
dc.contributor.alternativeauthor | 이준철 | - |
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