DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, Ji Min | ko |
dc.date.accessioned | 2023-06-14T02:01:28Z | - |
dc.date.available | 2023-06-14T02:01:28Z | - |
dc.date.created | 2023-06-12 | - |
dc.date.issued | 2023-01-18 | - |
dc.identifier.citation | PEPTALK 2023 | - |
dc.identifier.uri | http://hdl.handle.net/10203/307253 | - |
dc.description.abstract | Inspired by the intrinsic nature of microRNA-mediated mRNA cleavage, we developed a microRNA-targeting mRNA as a switch platform called mRNA bridge mimetics to regulate translocation of proteins. Combinatorial treatment with cisplatin and miR-21-EZH2 axis-targeting CRISPR Self Check-In improved sensitivity to chemotherapeutic drugs. Using the endogenous mRNA decay mechanism, our platform is able to remodel a cell's natural biology to allow the entry of precise drugs into the nucleus, devoid of non-specific translocation. This strategy is promising for applications in which the reaction must be controlled via intracellular stimuli and modulates Cas9 proteins to ensure safe genome modification in diseased conditions. | - |
dc.language | English | - |
dc.publisher | Cambridge Healthtech Institute (CHI) | - |
dc.title | Cytosolic miRNA-Inducible Nuclear Translocation of CRISPR Protein for Disease-Specific Genome Modification | - |
dc.type | Conference | - |
dc.type.rims | CONF | - |
dc.citation.publicationname | PEPTALK 2023 | - |
dc.identifier.conferencecountry | US | - |
dc.identifier.conferencelocation | San Diego, CA | - |
dc.contributor.localauthor | Lee, Ji Min | - |
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